Digital Twin Scientist, Clinical Trials (Hybrid)

Xe7 Limited; Cleveland (OH); Hybrid; USD 150,000 - 190,000; Full time

Job summary

Xenon7 is seeking a senior specialist to lead digital-twin development for clinical trial design and decision support in an Indianapolis-based hybrid setting. You will collaborate with clinical scientists, biostatisticians, and data scientists to translate questions into quantitative strategies and deliver interpretable analyses guiding trial design and patient selection.

Your focus will be on digital twin validation, simulation of disease progression and treatment response, and communicating

Qualifications

• PhD in a quantitative field as listed.
• Experience with digital twins or clinical trial simulation.
• Strong programming skills in Python or R and reproducible workflows.

Responsibilities

• Lead the design, development, and validation of digital twins of patients, disease trajectories, treatment response, or clinical trials.
• Combine mechanistic, statistical, causal, and ML approaches to create fit-for-purpose digital twins.
• Define use cases with clinical and quantitative experts for each digital twin.
• Assess calibration, validation, robustness, transportability, uncertainty, and relevance.
• Develop reproducible workflows and reusable digital-twin components across programs.

Skills

Digital twin development

Python

R

Machine learning / AI

Clinical development knowledge

Cross-functional collaboration

Communication skills

Education

PhD in quantitative field

Tools

Version control

Cloud analytics

Job description

Xenon7 is seeking a senior specialist to lead digital-twin development for clinical trial design and decision support in an Indianapolis-based hybrid setting. You will collaborate with clinical scientists, biostatisticians, and data scientists to translate questions into quantitative strategies and deliver interpretable analyses guiding trial design and patient selection.

Your focus will be on digital twin validation, simulation of disease progression and treatment response, and communicating