Digital Twin Scientist - Clinical Trials & AI/ML

Xe7 Limited; Indianapolis (IN); Hybrid; USD 130,000 - 180,000; Full time

Job summary

Xenon7 is seeking a lead in digital twins and quantitative decision support to advance clinical trial design and development. You will design, validate, and apply digital twins and simulation methods, collaborating with clinical scientists, biostatisticians, and data engineers to inform protocol design and endpoint strategies.

You will translate complex data into actionable insights, ensure model interpretability and governance, and drive reproducible workflows across therapeutic programs in a

Qualifications

• PhD in data science, statistics, biostatistics, pharmacometrics, or a related quantitative field.
• Demonstrated experience developing digital twins, virtual patients, disease‑progression models, or clinical trial simulations.
• Strong programming skills in Python, R, or a comparable analytical language with reproducible workflows.

Responsibilities

• Lead the design, development, and validation of digital twins of patients, disease trajectories, treatment response, or clinical trials.
• Combine mechanistic, statistical, causal, and machine learning approaches to create fit‑for‑purpose digital twins.
• Define use cases with clinical and quantitative experts to address specific trial‑design decisions.
• Assess calibration, validation, robustness, transportability, and uncertainty using appropriate evaluation strategies.
• Develop reproducible workflows and reusable digital‑twin components across programs.
• Partner with trial teams to frame development questions and evaluate design options.
• Communicate assumptions, limitations, and insights clearly to technical and non‑technical stakeholders.
• Ensure governance, privacy, security, and scientific review requirements are met.

Skills

Digital twins

AI/ML

Python

R

Data analysis

Statistical modeling

Clinical development

Education

PhD in data science/biostatistics/pharmacometrics/engineering

Tools

Cloud platforms

Git/version control

Job description

Xenon7 is seeking a lead in digital twins and quantitative decision support to advance clinical trial design and development. You will design, validate, and apply digital twins and simulation methods, collaborating with clinical scientists, biostatisticians, and data engineers to inform protocol design and endpoint strategies.

You will translate complex data into actionable insights, ensure model interpretability and governance, and drive reproducible workflows across therapeutic programs in a