Clinical Data Scientist - Digital Twins & AI/ML

Workana LLC; Columbus (OH); Remote; USD 130,000 - 170,000; Full time

Benefits offered by this job

Competitive salary

Remote work with international teams

Contractor agreement

Career growth opportunities

Job summary

Workana LLC is seeking a Clinical Data Scientist to join a multidisciplinary team focused on digital twins, AI/ML, and clinical trial simulation. This is a fully remote opportunity for professionals collaborating with an international team in an English-speaking environment.

The role emphasizes designing and validating digital-twin models, integrating multi-modal data, and ensuring interpretability and auditability of analyses.

Qualifications

• PhD in Data Science, Statistics, Biostatistics, Pharmacometrics, Computer Science, Biomedical Informatics, or a related quantitative field.
• Demonstrated experience developing digital twins, virtual patients, disease-progression models, or clinical trial simulations.
• Strong experience applying machine learning, statistical modeling, causal inference, or simulation to healthcare, pharmaceutical, or complex biomedical data.
• Advanced programming skills in Python
• Sufficient clinical-development knowledge to frame quantitative research questions and collaborate effectively with trial experts.

Responsibilities

• Lead the design, development, calibration, and validation of digital twins for patients, disease progression, and trial outcomes using clinical trial and external data.
• Combine machine learning, statistical modeling, causal inference, and mechanistic approaches to build fit-for-purpose computational models.
• Partner with trial teams to evaluate protocol design options, including target populations, eligibility, enrichment strategies, endpoints, and dosing.
• Analyze and integrate multi-modal datasets, including clinical trials, biomarkers, real-world data, digital health, imaging, and omics.
• Collaborate with data engineering and platform teams to build reproducible pipelines, reusable digital-twin components, and analysis-ready datasets.
• Work alongside biostatisticians and pharmacometricians to ensure digital-twin outputs complement established trial-design methods.
• Ensure model quality, interpretability, auditability, and responsible use by defining clear decision contexts, success criteria, and limitations.

Skills

Python programming

Machine learning

Statistical modeling

Causal inference

Education

PhD in Data Science or related quantitative field

Tools

AWS

GCP

Azure

Job description

is the largest remote work platform for talent in Latin America. Our client is an innovative clinical development organization driving healthcare forward through advanced digital twins, AI/ML, and computational modeling. They partner with multidisciplinary teams across life sciences to translate complex biological and trial data into quantitative strategies that optimize clinical trial design, endpoint selection, and patient outcomes.

Clinical Data Scientist

Digital Twins, AI/ML, and Clinical Trial Simulation

to join a multidisciplinary team of physicians, biostatisticians, pharmacometricians, and data engineers. This is a fully remote opportunity for professionals based in Latin America, working closely with an international team in an English-speaking environment.

Responsibilities

• Lead the design, development, calibration, and validation of digital twins for patients, disease progression, and trial outcomes using clinical trial and external data.
• Combine machine learning, statistical modeling, causal inference, and mechanistic approaches to build fit-for-purpose computational models.
• Partner with trial teams to evaluate protocol design options, including target populations, eligibility, enrichment strategies, endpoints, and dosing.
• Analyze and integrate multi-modal datasets, including clinical trials, biomarkers, real-world data, digital health, imaging, and omics.
• Collaborate with data engineering and platform teams to build reproducible pipelines, reusable digital-twin components, and analysis-ready datasets.
• Work alongside biostatisticians and pharmacometricians to ensure digital-twin outputs complement established trial-design methods.
• Ensure model quality, interpretability, auditability, and responsible use by defining clear decision contexts, success criteria, and limitations.

Required Qualifications

• PhD in Data Science, Statistics, Biostatistics, Pharmacometrics, Computer Science, Biomedical Informatics, or a related quantitative field.
• Demonstrated experience developing digital twins, virtual patients, disease-progression models, or clinical trial simulations.
• Strong experience applying machine learning, statistical modeling, causal inference, or simulation to healthcare, pharmaceutical, or complex biomedical data.
• Advanced programming skills in Python
• Sufficient clinical-development knowledge to frame quantitative research questions and collaborate effectively with trial experts.

Bonus Points

• Direct experience supporting clinical trial design, protocol development, model-informed drug development (MIDD), or regulatory-facing quantitative evidence.
• Expertise in Bayesian modeling, survival analysis, longitudinal modeling, adaptive trial design, or synthetic control arms.
• Experience working with scalable cloud-based analytical environments (AWS, GCP, or Azure).
• Experience working with clinical data standards and multi-modal biomedical data integration.

Benefits & Conditions

• Competitive salary with travel expenses covered when travel is required.
• Flexible work arrangements (Hybrid in Indianapolis, IN, or Fully Remote within the U.East Coast with occasional travel).
• Dynamic career growth with innovative, high-impact enterprise projects.
• Long-term independent contractor agreement.