CRISPR gRNA Process Development Scientist

Eurofins; Boston (MA); On-site; USD 44,000 - 56,000; Full time

Benefits offered by this job

Medical, dental, vision

Life and disability insurance

401(k) with company match

Paid vacation & holidays

Bonus eligibility

Job summary

Eurofins USA PSS Insourcing Solutions in Boston, MA, is seeking a process development scientist to join the guide-RNA (gRNA) process development team. The successful candidate will synthesize, purify, and characterize gRNAs to develop drug substance manufacturing processes and controls for programs in clinical development.

You will execute solid-phase synthesis and purification, perform routine analytics (HPLC/UV-Vis), prepare buffers, maintain lab notebooks, and uphold safety while supporting

Qualifications

• B.S./M.S. degree in chemistry, chemical engineering, or biochemistry (or related field) with at least 2 years of relevant laboratory industry experience.
• Experience with oligonucleotide synthesis and purification equipment (experience with gRNA or longmer synthesis and purification development is a plus).
• Experience operating analytical equipment such as AKTA chromatography systems, Agilent U/HPLC, gel electrophoresis, and NanoDrop.
• Experience with Tangential Flow Filtration (TFF) is required.
• Ability to follow SOPs for routine analytical support.
• Experience with Benchling and good documentation practices.
• Strong safety focus, attention to detail, and time management.
• Excellent communication and collaboration skills.
• Analytical mindset and problem-solving ability.
• Curiosity and ability to work in a fast-paced environment.

Responsibilities

• Execute solid-phase synthesis and purification experiments to support process development, scale-up, and transfer of oligonucleotide drug substance manufacturing.
• Execute routine analytics including HPLC and UV-Vis.
• Prepare buffers, reagents, and stock solutions used for process development activities, following established recipes and SOPs.
• Compile and present data to team members and key stakeholders.
• Maintain an updated lab notebook, order materials, maintain lab equipment, and support equipment troubleshooting as needed.
• Uphold lab safety to the highest level of standards.

Skills

Oligonucleotide synthesis

Purification methods

Analytical instrumentation

HPLC

UV-Vis

Benchling

Documentation

Lab safety

Communication

Problem solving

Education

B.S./M.S. in chemistry/biochemistry

Tools

AKTA chromatography systems

Agilent U/HPLC

NanoDrop

Tangential Flow Filtration (TFF)

Job description

Eurofins USA PSS Insourcing Solutions in Boston, MA, is seeking a process development scientist to join the guide-RNA (gRNA) process development team. The successful candidate will synthesize, purify, and characterize gRNAs to develop drug substance manufacturing processes and controls for programs in clinical development.

You will execute solid-phase synthesis and purification, perform routine analytics (HPLC/UV-Vis), prepare buffers, maintain lab notebooks, and uphold safety while supporting