Chemical Engineer: Drug Substance Process Design & Scale-Up

BioSpace; Indianapolis (IN); On-site; USD 68,000 - 174,000; Full time

Benefits offered by this job

Bonus program

Comprehensive benefits

401(k) and pension

Job summary

Lilly is seeking a Chemical Engineer to design and scale-up crystallization processes for drug substances at the Indianapolis site. You will work with process chemists, analytical chemists, and engineers to accelerate development from pre-clinical to product commercialization.

The role emphasizes PAT, crystallization optimization, and robust process understanding, with opportunities to publish and contribute to new technologies.

Qualifications

• B.S. or M.S. in chemical engineering or closely related field.
• Authorized to work in the United States on a full-time basis.
• Hands-on contributor with strong lab skills in chemistry & engineering.

Responsibilities

• Generate process design and unit operation knowledge for small molecules and modalities.
• Ensure successful scale-up of processes through engineering principles.
• Design and execute lab experiments including reactors for crystallization design.
• Develop drug substance processes and manufacturing technologies for API properties.
• Leverage PAT, continuous processing, and modeling to optimize crystallization.
• Characterize kinetics, mechanisms, and separations with engineering tools.
• Transfer process knowledge to internal/external sites and provide oversight.
• Publish and present original research at conferences and in journals.

Skills

Synthetic organic chemistry

Crystallization process design

PAT & analytical techniques

Lab-to-manufacturing transfer

Team collaboration

Education

Chemical engineering (B.S./M.S.)

Tools

XRPD

DSC

TGA

IR spectroscopy

Raman spectroscopy

FBRM

Microscopy

Job description

Lilly is seeking a Chemical Engineer to design and scale-up crystallization processes for drug substances at the Indianapolis site. You will work with process chemists, analytical chemists, and engineers to accelerate development from pre-clinical to product commercialization.

The role emphasizes PAT, crystallization optimization, and robust process understanding, with opportunities to publish and contribute to new technologies.