Cell Engineering Scientist – Target Validation & Assays

BioSpace; Thousand Oaks (CA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Retirement and Savings Plan

Health and welfare plans

Discretionary annual bonus

Stock-based incentives

Flexible work models

Job summary

Amgen seeks a highly motivated Scientist in Cell Engineering & Functional Target Validation to support the Surface Biology program. You will engineer target-specific cellular models, establish reporter systems, and execute functional screening assays to guide early pipeline decisions.

Key responsibilities include designing genome editing strategies, validating reporter lines, and presenting data to cross-functional teams in a fast-paced, collaborative environment.

Qualifications

• PhD in Molecular Biology, Cell Biology, Biotechnology or related field with strong science track record.
• Experience in genome editing and genetic perturbation in mammalian cells.
• Proven ability to design and execute cell-based functional assays.
• Experience with reporter systems and high-throughput validation workflows.
• Excellent collaboration and clear communication across teams.

Responsibilities

• Design and implement genome editing and perturbation strategies to generate cellular models for surface target validation.
• Engineer and characterize reporter cell lines and quantitative assays for target expression and localization.
• Develop functional assays using luminescence and fluorescence readouts to support validation workflows.
• Perform flow cytometry and cell sorting to verify target expression in engineered models.
• Maintain electronic lab notebooks and present datasets in cross-functional forums.

Skills

Genome editing

Reporter assays

Cell engineering

High-throughput validation

Team collaboration

Education

PhD

Masters + 2 years experience

Bachelors + 4 years experience

Tools

CRISPR systems

RNP electroporation

Lentiviral transduction

Flow cytometry

Reporter cell line engineering

Job description

Amgen seeks a highly motivated Scientist in Cell Engineering & Functional Target Validation to support the Surface Biology program. You will engineer target-specific cellular models, establish reporter systems, and execute functional screening assays to guide early pipeline decisions.

Key responsibilities include designing genome editing strategies, validating reporter lines, and presenting data to cross-functional teams in a fast-paced, collaborative environment.