Cell Biologist: Drug Discovery & Assay Development

Topos Bio; South San Francisco (CA); In loco; USD 110.000 - 170.000; Tempo pieno

Descrizione del lavoro

Topos Bio is seeking a cell biologist to develop and execute cell-based assays for validating computational predictions and supporting medicinal chemistry efforts.

You will work at the interface of disease biology, protein biophysics, and drug screening, building robust mammalian assays and coordinating with computational scientists.

This role requires a PhD and hands-on experience with disease-relevant cellular models and high-throughput screening platforms.

Competenze

• Strong foundation in mammalian cell culture and cellular assay development.
• Experience with disease-relevant cellular models.
• Ability to troubleshoot complex biological systems and optimize experimental protocols.
• Track record of productivity and effective collaboration.

Mansioni

• Develop and optimize mammalian cell-based assays for disordered protein targets.
• Execute phenotypic and reporter-based screening campaigns to validate computational hits.
• Characterize compound activity and support structure-activity relationship studies.
• Collaborate with computational scientists to integrate experimental data with modeling workflows.
• Establish robust assay protocols and quality control metrics.

Conoscenze

Cell culture

Assay development

Disease models

Troubleshooting

Collaboration

Formazione

PhD in cell and molecular biology

Strumenti

Reporter assays

High-throughput screening (HTS) platforms

Descrizione del lavoro

Topos Bio is seeking a cell biologist to develop and execute cell-based assays for validating computational predictions and supporting medicinal chemistry efforts.

You will work at the interface of disease biology, protein biophysics, and drug screening, building robust mammalian assays and coordinating with computational scientists.

This role requires a PhD and hands-on experience with disease-relevant cellular models and high-throughput screening platforms.