Cellular Biologist

Topos Bio; South San Francisco (CA); Sur place; USD 110 000 - 170 000; Plein temps

Résumé du poste

Topos Bio is seeking a cell biologist to develop and execute cell-based assays for validating computational predictions and supporting medicinal chemistry efforts.

You will work at the interface of disease biology, protein biophysics, and drug screening, building robust mammalian assays and coordinating with computational scientists.

This role requires a PhD and hands-on experience with disease-relevant cellular models and high-throughput screening platforms.

Qualifications

• Strong foundation in mammalian cell culture and cellular assay development.
• Experience with disease-relevant cellular models.
• Ability to troubleshoot complex biological systems and optimize experimental protocols.
• Track record of productivity and effective collaboration.

Responsabilités

• Develop and optimize mammalian cell-based assays for disordered protein targets.
• Execute phenotypic and reporter-based screening campaigns to validate computational hits.
• Characterize compound activity and support structure-activity relationship studies.
• Collaborate with computational scientists to integrate experimental data with modeling workflows.
• Establish robust assay protocols and quality control metrics.

Connaissances

Cell culture

Assay development

Disease models

Troubleshooting

Collaboration

Formation

PhD in cell and molecular biology

Outils

Reporter assays

High-throughput screening (HTS) platforms

Description du poste

Topos Bio

At Topos Bio, we're pioneering drug discovery for intrinsically disordered proteins—targets that have eluded conventional approaches in neurodegeneration, oncology, and cardiometabolic disease.

We're seeking a cell biologist to develop and execute cell-based assays for validating computational predictions and supporting medicinal chemistry efforts. You'll work at the interface of disease biology, protein biophysics, and drug screening.

What you will do

• Develop and optimize mammalian cell-based assays for disordered protein targets

• Execute phenotypic and reporter-based screening campaigns to validate computational hits

• Characterize compound activity and support structure-activity relationship studies

• Collaborate with computational scientists to integrate experimental data with modeling workflows

• Establish robust assay protocols and quality control metrics

What we are looking for

• Strong foundation in mammalian cell culture and cellular assay development

• Experience with disease-relevant cellular models

• Ability to troubleshoot complex biological systems and optimize experimental protocols

• Track record of productivity and effective collaboration

Preferred

• PhD in cell and molecular biology with focus on disease models

• Industry experience in drug discovery or biotech

• Experience with reporter assays and high-throughput screening platforms

• Familiarity with oncology, neurodegeneration, or metabolic disease models

• Track record of developing novel cellular assays or screening approaches