Cell Biologist & Assay Developer

Flagship Pioneering, Inc.; Watertown (MA); On-site; USD 100,000 - 127,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Other benefits

Job summary

Abiologics, Inc. seeks a highly motivated cell biologist and assay developer to join its Pharmacology team in Watertown, MA. You will develop and execute biochemical and cell-based assays to advance the Syntein platform and support progression of the pipeline.

Role requires a PhD in molecular or cell biology with relevant experience, plus hands-on mammalian cell culture, transfection, viral transduction, and bioanalytical techniques. Strong collaboration and data reporting are essential.

Qualifications

• PhD in molecular or cell biology with up to 2 years relevant experience; industry experience is preferred.
• Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, lentiviral transduction, and reporter cell lines.
• Proficient in industry-standard cell-based assays and bioanalytical techniques including TR-FRET, Lumit, ELISA, Western blot, flow cytometry, enzymatic activity, and reporter gene assays; experience with cellular/high content imaging and image analysis a plus.

Responsibilities

• Design and execute cell-based and biochemical assays to assess Syntein activity, target engagement, and mechanism of action to drive discovery programs.
• With guidance from manager, conceptualize and develop novel assays for diverse target classes and disease areas.
• Collaborate with the Pharmacology team on biochemistry and biophysics projects and provide cell biology expertise.
• Contribute to in vivo and ex vivo pharmacology activities to progress projects and the platform.
• Collaborate cross-functionally to enable novel methods, assays and screening workflows, including optimization of assays for incorporation into screening funnels and cross-training of colleagues on methods.
• Ensure rapid generation and accurate reporting of high-quality data and collaborate with Computational Design and Chemistry & Screening teams to drive design-make-test cycles.
• Effectively communicate scientific findings and ideas to a diverse team both informally and at project team meetings.

Skills

Cell biology

Assay development

In vivo pharmacology

Data analysis

Communication

Education

PhD in molecular or cell biology

Tools

TR-FRET

Lumit

ELISA

Western blot

Flow cytometry

Job description

Abiologics, Inc. seeks a highly motivated cell biologist and assay developer to join its Pharmacology team in Watertown, MA. You will develop and execute biochemical and cell-based assays to advance the Syntein platform and support progression of the pipeline.

Role requires a PhD in molecular or cell biology with relevant experience, plus hands-on mammalian cell culture, transfection, viral transduction, and bioanalytical techniques. Strong collaboration and data reporting are essential.