In Vitro Pharmacology Scientist – Cell Biology Focus

Pioneering Medicines; Watertown (MA); On-site; USD 100,000 - 127,000; Full time

Benefits offered by this job

Healthcare benefits

Annual incentive program

Retirement benefits

Job summary

Abiologics, Inc. is seeking a highly motivated cell biologist to join our Pharmacology team.

You will develop and execute cell-based and biochemical assays to support our Syntein platform progression and, in some cases, contribute to in vivo or ex vivo pharmacology activities, collaborating across Abiologics to drive growth. The role requires a PhD in molecular or cell biology and hands-on experience with mammalian cell culture, assay development, and data reporting.

Qualifications

• PhD in molecular or cell biology or related discipline with up to 2 years relevant experience; industry experience is preferred
• Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, lentiviral transduction, and reporter cell lines
• Proficient in industry-standard cell-based assays and bioanalytical techniques including TR-FRET, Lumit, ELISA, Western blot, flow cytometry, enzymatic activity, and reporter gene assays; experience with cellular/high content imaging and image analysis a plus (e.g., Incucyte, Phenix)
• Experienced with primary cell culture and characterization, including tissue dissociation
• Experienced in assay development and testing in model systems and human with good understanding of analytical and pre-analytical methods and solutions
• Demonstrated ability to independently design, develop and optimize diverse cell-based functional assays (e.g., intracellular signaling) and interpret complex results
• Strong proficiency in renal disease biology and preclinical kidney models is highly desirable
• In vivo pharmacology experience would be a plus
• Proficiency in laboratory automation and semi-automated screening workflows is a plus
• Industry level experience with best practices related to data records creation and maintenance and workflow integrity
• Demonstrated ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality

Responsibilities

• Design and execute cell-based and biochemical assays to assess Syntein TM activity, target engagement, and mechanism of action to drive discovery programs
• With guidance from manager, conceptualize and develop novel assays for diverse target classes and disease areas
• Collaborate with the Pharmacology team on biochemistry and biophysics projects and provide cell biology expertise
• Contribute to in vivo and ex vivo pharmacology activities to progress projects and the platform
• Collaborate cross-functionally to enable novel methods, assays and screening workflows, including optimization of assays for incorporation into screening funnels and cross-training of colleagues on methods
• Ensure rapid generation and accurate reporting of high-quality data and collaborate with Computational Design and Chemistry & Screening teams to drive design-make-test cycles
• Effectively communicate scientific findings and ideas to a diverse team both informally and at project team meetings

Skills

Cell culture

Assay development

Biochemical assays

Lentiviral transduction

Reporter cell lines

TR-FRET

LumIt

Flow cytometry

In vivo pharmacology

Data analysis

Automation / screening workflows

Education

PhD in molecular or cell biology

Tools

Incucyte

Phenix

Job description

Abiologics, Inc. is seeking a highly motivated cell biologist to join our Pharmacology team.

You will develop and execute cell-based and biochemical assays to support our Syntein platform progression and, in some cases, contribute to in vivo or ex vivo pharmacology activities, collaborating across Abiologics to drive growth. The role requires a PhD in molecular or cell biology and hands-on experience with mammalian cell culture, assay development, and data reporting.