Cardiac In Vitro Scientist — iPSC & Contractility Assays

Atrium Therapeutics; San Diego (CA); Presencial; USD 81 000 - 99 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

401(k) with employer match

Wellness program

Education reimbursement

Unlimited time off

Resumo da oferta

Atrium Therapeutics is seeking a Postdoctoral Scientist to develop in vitro cardiac assays for siRNA-based antibody–oligonucleotide conjugate programs using human iPSC-derived cardiomyocytes, primary adult cardiomyocytes, and engineered cardiac tissues.

You will connect functional data with target knockdown and molecular endpoints to guide candidate selection in a hands-on role with mentorship and opportunities to publish.

Qualificações

• Ph.D. in a relevant discipline completed by the start date.
• Hands-on experience culturing and functionally characterizing cardiomyocytes.
• Experience with calcium imaging or contractility assays.
• Ability to design experiments and interpret quantitative data.
• Experience with siRNA or oligonucleotide therapeutics preferred.
• Strong communication and collaboration skills.

Responsabilidades

• Design and execute in vitro studies using human iPSC-derived cardiomyocytes, primary adult cardiomyocytes, and engineered cardiac tissues.
• Develop, optimize, and apply robust functional assays, including calcium transient imaging and Mantarray-based contractility measurements.
• Analyze and integrate functional, target-knockdown, and downstream molecular data to characterize pharmacology and mechanism of action.
• Lead a defined research project and collaborate with cross-functional scientists on study design and interpretation.
• Communicate research findings through documentation, internal presentations, peer-reviewed publications and external presentations.

Conhecimentos

Cardiac physiology

Pharmacology

Bioengineering

Cell biology

Molecular biology

Data analysis

Statistical analysis

Publications

Formação académica

Ph.D. in cardiac physiology, pharmacology, bioengineering, cell biology, molecular biology, or related discipline

Ferramentas

Mantarray platform

ELN

Prism

Microsoft Office Suite

Data analysis software

Descrição da oferta de emprego

Atrium Therapeutics is seeking a Postdoctoral Scientist to develop in vitro cardiac assays for siRNA-based antibody–oligonucleotide conjugate programs using human iPSC-derived cardiomyocytes, primary adult cardiomyocytes, and engineered cardiac tissues.

You will connect functional data with target knockdown and molecular endpoints to guide candidate selection in a hands-on role with mentorship and opportunities to publish.