Bioconjugation Scientist I — Cardiac RNA Delivery

Atrium Therapeutics; San Diego (CA); On-site; USD 128,000 - 142,000; Full time

Benefits offered by this job

Stock options

RSUs

401(k) match

Wellness program

Job summary

Atrium Therapeutics is seeking a hands-on Scientist I to join the Integrated Discovery and Technical Development Team, focusing on design, synthesis, purification, characterization and scale-up of antibody-oligonucleotide conjugates (AOCs) that deliver siRNA to cardiomyocytes.

This bench role collaborates with Biology, Developmental Sciences, Analytical, and Technical Operations to advance candidates from discovery through IND-enabling studies.

Qualifications

• Ph.D. in Chemistry, Chemical Biology, Biochemistry or related field with 0–2 years postdoc/industry.
• M.S. in related field with 3–6 years industry experience.
• B.S./B.A. in related field with 6–9 years industry experience.
• Hands-on bioconjugation chemistry experience (antibody-drug conjugate, antibody-oligonucleotide conjugate, peptide conjugates or related biomolecule conjugation approaches)
• Working knowledge of oligonucleotide chemistry and/or monoclonal antibody structure and handling
• Experience with purification techniques (HIC, SEC, IEX, affinity, and/or mixed-mode chromatography and tangential flow filtration)

Responsibilities

• Synthesize, purify, and characterize antibody-oligonucleotide conjugates (AOCs).
• Develop, optimize, and support CDMO tech transfer of conjugation and purification processes.
• Collaborate cross-functionally to advance AOCs to IND-enabling activities and late-stage development.
• Develop analytical methods to characterize intermediates and products (IEX, HIC, RP-HPLC, LC-MS).

Skills

Bioconjugation chemistry

Analytical characterization

Lab record-keeping

Cross-functional communication

Education

Ph.D. in Chemistry/related

M.S. in related field

B.S./B.A. in related field

Tools

HIC

SEC

IEX

Affinity chromatography

Tangential flow filtration

LC-MS

HPLC

CE-SDS

icIEF

UV-Vis

Job description

Atrium Therapeutics is seeking a hands-on Scientist I to join the Integrated Discovery and Technical Development Team, focusing on design, synthesis, purification, characterization and scale-up of antibody-oligonucleotide conjugates (AOCs) that deliver siRNA to cardiomyocytes.

This bench role collaborates with Biology, Developmental Sciences, Analytical, and Technical Operations to advance candidates from discovery through IND-enabling studies.