CAR-T Cell Therapy Scientist II/I – Immunology Discovery

U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.; Cambridge (MA); On-site; USD 109,000 - 202,000; Full time

Benefits offered by this job

Performance-based incentive

401(k) with company match

Health benefits

Life benefits

Vacation and paid time off

Job summary

Novartis Institutes for BioMedical Research, Inc. in Cambridge, MA seeks a PhD scientist with 1–2 years of related experience to join a multidisciplinary cell therapeutics discovery team focused on CAR‑T engineering and T‑cell biology.

You will design and evaluate CAR constructs, perform functional testing, and collaborate across research partners to drive translational opportunities. The role emphasizes high‑quality data generation, cross‑functional teamwork, and contributions to future

Qualifications

• - PhD in immunology, cell biology, molecular biology, bioengineering, or related discipline with 1–2 years of relevant experience.
• - Hands‑on experience in CAR‑T engineering or engineered T‑cell approaches.
• - Expertise in ex vivo cell characterization using multicolor flow cytometry (FACS) and cytokine profiling methods such as ELISA, MSD, or Luminex.
• - Prior experience with immune‑cell isolation techniques and culture of primary human T cells.
• - Experience designing and generating lentiviral CAR constructs and interpreting functional data for construct optimization.
• - Able to independently design and execute experiments, prioritize research activities, and provide evidence‑based recommendations.
• - Strong collaboration and scientific communication skills.

Responsibilities

• Design and execute innovative research to advance next‑generation CAR‑T approaches.
• Design, generate, and evaluate complex lentiviral constructs for logic‑gated CAR‑T approaches.
• Perform hands‑on functional testing and optimization of CAR‑T cells and test analytical methods.
• Execute cell‑line engineering to develop models for evaluating function and inform construct selection.
• Integrate findings across engineering, in vitro biology, and in vivo pharmacology to inform prioritization.
• Drive projects to meet timelines while ensuring data quality and integrity.
• Comply with SOPs and maintain meticulous records in ELN.
• Contribute to drafting technical documents and regulatory submissions as needed.
• Present results and recommendations to cross‑functional teams and leadership.

Skills

CAR‑T engineering

Flow cytometry

Lentiviral CAR constructs

T‑cell biology

Cross‑functional collaboration

Education

PhD in immunology/cell biology

Tools

Flow cytometer

ELISA

MSD

Luminex

Job description

Novartis Institutes for BioMedical Research, Inc. in Cambridge, MA seeks a PhD scientist with 1–2 years of related experience to join a multidisciplinary cell therapeutics discovery team focused on CAR‑T engineering and T‑cell biology.

You will design and evaluate CAR constructs, perform functional testing, and collaborate across research partners to drive translational opportunities. The role emphasizes high‑quality data generation, cross‑functional teamwork, and contributions to future