CAR-T Scientist I/II — Immuno-Oncology Research

Novartis AG; Cambridge (MA); On-site; USD 109,000 - 202,000; Full time

Job summary

Novartis seeks a highly motivated PhD scientist to join a multidisciplinary cell therapeutics discovery team in Cambridge, MA, focusing on CAR-T engineering and T-cell biology to advance next-generation cell therapies.

You will design, generate, and evaluate complex lentiviral CAR constructs, perform functional testing, analyze data, and collaborate across teams to inform candidate selection and translational opportunities.

Qualifications

• PhD in immunology or related field with relevant experience.
• Hands-on CAR-T engineering experience.
• Experience with multicolor flow cytometry and cytokine profiling.
• Experience isolating immune cells and culturing primary human T cells.
• Experience designing and generating lentiviral CAR constructs.
• Strong independent design and problem-solving skills.
• Ability to work in a fast-paced, collaborative environment.
• Strong collaboration and scientific communication.

Responsibilities

• Design and execute research to advance next-gen CAR-T approaches.
• Design, generate, and evaluate complex lentiviral CAR constructs.
• Perform functional testing and optimize CAR-T cells; test new analytical methods.
• Engineer cell lines to evaluate function and inform construct choice.
• Integrate findings across disciplines to guide candidate prioritization.
• Drive projects to meet timelines with high data quality.
• Follow SOPs and maintain rigorous lab records.
• Draft technical documents for programs and regulatory submissions.
• Present results and recommendations to teams and leadership.

Skills

CAR-T engineering

Flow cytometry

Immune cell isolation

Lentiviral constructs

Data interpretation

Experimental design

Collaboration

Scientific communication

Education

PhD in immunology

Tools

Flow cytometer

Lentiviral vectors

ELISA

MSD

Luminex

Job description

Novartis seeks a highly motivated PhD scientist to join a multidisciplinary cell therapeutics discovery team in Cambridge, MA, focusing on CAR-T engineering and T-cell biology to advance next-generation cell therapies.

You will design, generate, and evaluate complex lentiviral CAR constructs, perform functional testing, analyze data, and collaborate across teams to inform candidate selection and translational opportunities.