Biologics Optimization Lead Scientist - Protein Design & AI

Johnson Johnson; Spring House (PA); On-site; USD 140,000 - 210,000; Full time

Job summary

Johnson & Johnson’s Innovative Medicine Biologics Discovery group in Spring House, PA seeks a Principal Scientist, Biologics Optimization. The role leads protein and antibody engineering efforts to translate design insights into improved biological function for multiple therapeutic programs.

The candidate will partner with cross-functional teams, apply AI/ML-enabled design, and drive development of optimized protein sequences and platforms across modalities.

Qualifications

• Deep expertise in antibody and protein engineering.
• Experience with biologics optimization and therapeutic modalities.
• Familiarity with computational/AI-driven design approaches.

Responsibilities

• Lead biologics optimization efforts across multiple programs.
• Develop and champion deployment of optimization strategies linking sequence, structure, developability and function.
• Apply computational and AI/ML approaches to guide design and hit selection.
• Present scientific findings to multi-functional teams and drive project timelines.

Skills

Antibody engineering

Protein engineering

AI/ML design

Computational design

Biologics developability

Tools

Display technologies

Structure modeling

Job description

Johnson & Johnson’s Innovative Medicine Biologics Discovery group in Spring House, PA seeks a Principal Scientist, Biologics Optimization. The role leads protein and antibody engineering efforts to translate design insights into improved biological function for multiple therapeutic programs.

The candidate will partner with cross-functional teams, apply AI/ML-enabled design, and drive development of optimized protein sequences and platforms across modalities.