Principal Scientist, Biologics Optimization

Johnson Johnson; Spring House (PA); On-site; USD 140,000 - 210,000; Full time

Job summary

Johnson & Johnson’s Innovative Medicine Biologics Discovery group in Spring House, PA seeks a Principal Scientist, Biologics Optimization. The role leads protein and antibody engineering efforts to translate design insights into improved biological function for multiple therapeutic programs.

The candidate will partner with cross-functional teams, apply AI/ML-enabled design, and drive development of optimized protein sequences and platforms across modalities.

Qualifications

• Deep expertise in antibody and protein engineering.
• Experience with biologics optimization and therapeutic modalities.
• Familiarity with computational/AI-driven design approaches.

Responsibilities

• Lead biologics optimization efforts across multiple programs.
• Develop and champion deployment of optimization strategies linking sequence, structure, developability and function.
• Apply computational and AI/ML approaches to guide design and hit selection.
• Present scientific findings to multi-functional teams and drive project timelines.

Skills

Antibody engineering

Protein engineering

AI/ML design

Computational design

Biologics developability

Tools

Display technologies

Structure modeling

Job description

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com .

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function: Discovery & Pre-Clinical/Clinical Development

Job Sub Function: Biotherapeutics R&D

Job Category: Scientific/Technology

All Job Posting Locations: Spring House, Pennsylvania, United States of America

Job Description

About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for Principal Scientist, Biologics Optimization in Spring House, PA

Purpose: The Biologics Optimization team within Biologics Discovery is responsible for the design and optimization of lead biologic variants across multiple therapeutic modalities to achieve differentiated functional outcomes aligned with desired therapeutic mechanism of action (MoA). In this position, the Principal Scientist will serve as a scientific leader and subject matter expert in biologics optimization, driving and dissecting protein engineering strategies that translate molecular design into improved biological function across diverse therapeutic modalities. This role requires deep expertise in antibody and protein engineering, computational and AI/ML-enabled design approaches, and mechanism-driven biologics discovery expertise. The Principal Scientist will provide scientific leadership in function-based biologics optimization, translating therapeutic mechanisms of action and molecular design insights into differentiated functional outcomes across diverse therapeutic modalities. This role will drive the design and delivery of fit-for-purpose optimized protein sequences and evaluate critical attributes-including biological function, potency, selectivity, production, and developability-using display technologies, structure- and modeling-guided design, and emerging computational and AI/ML approaches. The successful candidate will partner closely with Therapeutic Area scientists, computational scientists, protein engineers, and drug discovery teams to develop and implement optimization strategies that enhance potency, selectivity, efficacy, and overall therapeutic performance. This role offers an exciting opportunity to not only engage in the discovery and molecular engineering of biotherapeutics, but to develop new processes and technologies in collaboration with other functional group with the opportunity to lead project teams and interact with world-class Therapeutic Area scientists.

You will be responsible for:

• Lead biologics optimization efforts across multiple therapeutic programs, translating target biology and desired mechanisms of action into rational protein engineering strategies.
• Serve as a subject matter expert in function-driven optimization: develop and champion novel development efforts aimed at fulfilling strategic long-term antibody design/optimization initiatives and validation.
• Develop optimization strategies that integrate antibody sequence, structure, developability, and biological function to achieve program objectives.
• Develop and champion novel display-based platform development efforts aimed at fulfilling strategic long-term antibody design/optimization initiatives and validation.
• Lead/participate on project teams to advance discovery portfolio projects. Act as a point of accountability for optimization engineering asks and manage project timelines independently.
• Partner with teams across TD/TA to define critical functional hypotheses and establish screening cascades that enable MoA-driven decision making.
• Apply computational, AI/ML, and data-driven approaches to guide variant design, library construction, sequence prioritization, and hit selection.
• Evaluate emerging technologies and develop innovative approaches to accelerate biologics optimization workflows and therapeutic discovery.
• Independently present/defend scientific findings in multi-functional project teams/initiatives.
• Independently plan,