Bioconjugation Scientist II – Protein Chemistry

Soufflé Therapeutics; Watertown (MA); On-site; USD 120,000 - 180,000; Full time

Job summary

Soufflé Therapeutics in Watertown, MA is seeking a Scientist II in Protein Science – Conjugation to advance bioconjugation methods and novel molecular modalities. You will help shape how a growing biotech builds conjugation chemistry and purification capabilities, owning tasks from day one.

You will contribute hands-on conjugation, purification, and analytical work to progress internal programs and external collaborations, with onsite collaboration in a dynamic team environment.

Qualifications

• 6+ years of relevant experience in academia and industry.
• Hands-on protein bioconjugation experience, especially antibody-drug conjugates.
• Experience with protein purification methods, such as affinity chromatography, ion exchange chromatography, and tangential flow filtration.
• Proficiency in analytical techniques for characterizing proteins and protein conjugates (SEC-HPLC, IEX-HPLC, RP-HPLC, SDS-PAGE, and mass spectrometry).

Responsibilities

• Leverage knowledge of protein and conjugation chemistry to prepare novel bioconjugates for in vitro and in vivo studies.
• Lead conjugation work supporting internal programs and collaborations, from planning through execution.
• Drive conjugation chemistry research into new conjugation modalities, payloads, and conjugate formats.
• Perform characterization of conjugates using SEC-HPLC, SDS-PAGE, and mass spectrometry.
• Represent the conjugation team in prioritization and cross-functional collaboration meetings.

Skills

Protein bioconjugation

Antibody-drug conjugates

Protein purification methods

Analytical techniques

Education

PhD in Chemistry/Biochemistry/Chemical Biology/Bioengineering

BS with 10+ years of conjugation industry experience

Tools

SEC‑HPLC

IEX‑HPLC

RP‑HPLC

SDS‑PAGE

Mass spectrometry

Job description

Soufflé Therapeutics in Watertown, MA is seeking a Scientist II in Protein Science – Conjugation to advance bioconjugation methods and novel molecular modalities. You will help shape how a growing biotech builds conjugation chemistry and purification capabilities, owning tasks from day one.

You will contribute hands-on conjugation, purification, and analytical work to progress internal programs and external collaborations, with onsite collaboration in a dynamic team environment.