Bioconjugation Scientist — 6-Month Lab Contract

Discover International; Philadelphia (Philadelphia County); On-site; USD 90,000 - 130,000; Full time

Job summary

Discover International is seeking a temporary, lab-based Bioconjugation Scientist for its Protein Sciences team in Philadelphia. The 6-month contract role involves bench work on protein purification, bioconjugation chemistry, and analytical characterization to support protein-toxin and siRNA-conjugate programs.

The ideal candidate will reliably execute experiments, document results in ELN, and collaborate with cross-functional teams in a fast-paced research environment.

Qualifications

• B.S./M.S. in Biochemistry, Chemistry, Chemical Engineering, Molecular Biology or related field.
• 5–8 years of hands-on industry lab experience in biotech/pharma/CDMO settings.
• Hands-on protein purification and chromatography experience (FPLC/AKTA, affinity, IEX, SEC).
• Direct bioconjugation experience; protein-toxin conjugates preferred.
• Experience with siRNA or oligonucleotide conjugation is desirable.
• Solid knowledge of analytical methods (SEC-HPLC, RP-HPLC, LC-MS, SDS-PAGE, UV-Vis).

Responsibilities

• Perform protein purification of recombinant proteins and bioconjugates using chromatography (FPLC/AKTA, affinity, IEX, SEC).
• Execute bioconjugation to generate protein-toxin conjugates and optimize reactions.
• Conjugate siRNA payloads to protein vehicles for various programs.
• Support analytical development and characterize proteins and conjugates (SDS-PAGE, HPLC, LC-MS).
• Maintain detailed ELN records and compliant lab documentation.
• Troubleshoot experiments, analyze data, and report results to the team.
• Collaborate with process development, analytical, and discovery biology teams.

Skills

Protein purification

Bioconjugation chemistry

Analytical techniques

Bench-based independence

ELN documentation

siRNA conjugation

Education

B.S./M.S. in Biochemistry, Chemistry, Chemical Engineering, Molecular Biology

Tools

FPLC/AKTA systems

Affinity chromatography

Ion-exchange chromatography

SEC/Size-exclusion

RP-HPLC

LC-MS

SDS-PAGE

Job description

Discover International is seeking a temporary, lab-based Bioconjugation Scientist for its Protein Sciences team in Philadelphia. The 6-month contract role involves bench work on protein purification, bioconjugation chemistry, and analytical characterization to support protein-toxin and siRNA-conjugate programs.

The ideal candidate will reliably execute experiments, document results in ELN, and collaborate with cross-functional teams in a fast-paced research environment.