Associate Scientist, Single-Cell Genomics & Neurocytometry

St. Jude Children's Research Hospital; Lauderdale Courts (TN); On-site; USD 66,000 - 114,000; Full time

Job summary

St. Jude Children’s Research Hospital is seeking an Associate Scientist to support the Single Cell Genomics Core and the Neurocytometry Core within the Department of Developmental Neurobiology.

You will independently perform single-cell sample processing, sequencing workflows, and multicolor panel design, while coordinating with investigators across programs to optimize tissue dissociation and library prep.

Qualifications

• The ideal candidate will have strong background in developmental biology, molecular biology, neuroscience, stem cell biology, or a closely related field.
• Excellent ability to design, execute, and troubleshoot independent experiments using established or new protocols.
• Experience with single-cell genomic workflows (e.g., 10x Genomics Chromium, single-cell RNA-seq library prep) is preferred.
• Familiarity with neural tissue dissociation and analysis of neuronal, glial, and other brain/spinal cord cell populations.
• Hands-on experience with flow cytometry and cell sorting instrumentation, including setup, calibration, and troubleshooting.
• Proficiency in molecular biology and designing and analyzing multi-color high-parameter cytometry panels.
• Experience with flow data analysis platforms (FlowJo, DIVA, OMIQ) and Microsoft Office products.
• Proven ability to train and support technicians, students, and investigators.
• Strong organizational and communication skills; collaborative, team-oriented approach.

Responsibilities

• Independently perform experiments using existing, modified, or new protocols.
• Accurately record procedures and data.
• Prepare and report results leading to posters, presentations, or publications.
• Set up protocols using new or modified lab techniques and troubleshoot experiments.
• Identify data relevant to analysis problems; organize and summarize data; report results.
• Independently perform single-cell sample processing and loading onto sequencing platforms (e.g., 10x Genomics Chromium).
• Coordinate sample intake, quality control, and sequencing run scheduling for the Single Cell Genomics Core.
• Establish, modify, and implement SOPs for maintenance and evaluation of flow cytometers.
• Independently perform instrument setup, calibration, and training; oversee instrument repair and service coordination.
• Train technicians, students, and investigators on cytometry concepts and data analysis.
• Collaborate to develop, evaluate, and optimize multicolor high-parameter cytometry assays.
• Perform regular cell sorting services and support users in cytometry-based approaches.
• Provide ongoing support for equipment maintenance, ordering, and purchasing as needed.
• Perform other duties to meet department and institution goals; maintain regular attendance.

Skills

Developmental biology

Molecular biology

Neuroscience

Stem cell biology

Single-cell workflows

Flow cytometry

Cell sorting

Panel design

Troubleshooting

Data analysis

Education

Bachelor's degree in a relevant scientific area

Tools

10x Genomics Chromium

DIVA

OMIQ

FlowJo

Cell sorters

Job description

St. Jude Children’s Research Hospital is seeking an Associate Scientist to support the Single Cell Genomics Core and the Neurocytometry Core within the Department of Developmental Neurobiology.

You will independently perform single-cell sample processing, sequencing workflows, and multicolor panel design, while coordinating with investigators across programs to optimize tissue dissociation and library prep.