Associate Scientist: Downstream Process Development

Proclinical Group; Cambridge (MA); On-site; USD 55,000 - 83,000; Part time

Job summary

Proclinical Group in Cambridge, MA is seeking an Associate Scientist II on a contract basis to join the CMC - DS Process Development Group. The role focuses on integrating novel chemistries into the oligonucleotide manufacturing platform and advancing process development.

The ideal candidate has a BS in Chemistry or Chemical Engineering, hands-on analytical lab experience, and proficiency with LC/HPLC, pH, osmolality and LC-MS.

Qualifications

• BS in Chemistry or Chemical Engineering required.
• Process development experience in chemical manufacturing.
• Strong analytical chemistry background with hands-on lab work.
• Experience running LC/HPLC analyses.
• Familiarity with pH, Osmolality, Conductivity, LC-MS.
• Excellent lab documentation and data recording.
• Knowledge of oligonucleotide manufacturing including Phosphoramidite chemistry

Responsibilities

• Support synthesis method development, optimization, and scale-up.
• Support downstream processing method development.
• Execute in-process analytical testing.
• Collaborate with researchers to develop robust processes for novel chemistries.
• Maintain accurate laboratory documentation.
• Maintain a safe and orderly lab environment.
• Assist with routine lab and equipment maintenance.

Skills

Analytical chemistry

Laboratory techniques

Documentation

Data recording

LC-HPLC

Oligonucleotide knowledge

Education

BS in Chemistry or Chemical Engineering

Tools

Agilent UNICORN software

LC-MS instrumentation

Job description

Associate Scientist - Contract - Cambridge, MA

Passionate about analytical chemistry and process development? Join a team advancing cutting-edge oligonucleotide manufacturing technologies.

Proclinical is seeking an Associate Scientist II will join the CMC - DS Process Development Group at our client's facility in the US.

Primary Responsibilities

The successful candidate will be supporting process development efforts to incorporate novel chemistries into the manufacturing platform.

Skills & Requirements

• Required: BS in Chemistry or Chemical Engineering
• Process development experience/background
• Strong analytical chemistry background and hands-on laboratory experience
• Chemistry background with experience running analytical testing, particularly LC/HPLC
• Understanding of analytical techniques such as pH, Osmolality, Conductivity, HPLC, and LC-MS
• Strong laboratory documentation and record-keeping practices
• Knowledge of oligonucleotide manufacturing, including: Phosphoramidite chemistry, Chromatography, and Ultrafiltration
• Experience with relevant analytical testing software, e.g., Agilent and UNICORN laboratory software

The Associate Scientist's responsibilities will be:

• Support oligonucleotide synthesis method development, optimization, and scale-up
• Support downstream processing method development
• Execute in-process analytical testing
• Partner with research and process scientists to develop robust processes for novel chemistries
• Maintain strong laboratory documentation and record-keeping
• Maintain a safe, clean, and orderly laboratory environment
• Assist with routine laboratory and equipment maintenance

By submitting this application, you confirm that you've read and understood our privacy policy, which informs you how we process and safeguard your data - https://www.proclinical.com/privacy-policy