Associate Director, Translational Oncology (AI-Driven)

Isomorphic Labs; Cambridge, Northern (MA, KY); Hybrid; USD 180,000 - 240,000; Full time

Job summary

Isomorphic Labs in Cambridge, MA seeks an Associate Director of Translational Medicine to lead strategy for oncology programs and drive biomarker and diagnostic initiatives. You will shape clinical trial design, collaborate across functions, and manage external partners to deliver robust translational data.

The role emphasizes AI-driven tools, cross-disciplinary leadership, and regulatory-experiential contributions to INDs, protocols, and briefing books, with a fast-paced, collaborative culture.

Qualifications

• Ph.D. or similar in biology or related field.
• 7+ years of translational experience within biotech or pharma including oncology.
• Proven success implementing and executing translational strategy, clinical biomarkers and diagnostic development in oncology studies.
• Experience working cross-functionally with key stakeholders internally as well as external vendors and collaborators.
• Significant expertise in cancer biology and drug development
• Strong appetite to work in an AI-first environment.
• Willingness to go beyond traditional assays and approaches, incorporating cutting edge methodologies that may enhance therapeutic probability of success and velocity.
• Sense of urgency and accountability to operate in a fast-paced environment.
• Flexibility to adapt to changing timelines and priorities.
• Strong leadership and excellent communication skills.

Responsibilities

• Lead and execute the Translational Medicine strategyacross oncology programs. Ensure readiness of clinical biomarker assays and delivery of corresponding data to address mechanism of action, predictive and prognostic insights, mechanisms of drug resistance and to inform future indications and combinations.
• Serve as a core member of the oncology program teams and subject matter expert for cancer biology. Collaborate with cross-functional teams to set the program strategy and clinical trial design across tumor types and drug modalities.
• Deliver clinically validated assays and advance companion diagnostic development for biomarker selected studies.
• Work closely with the early portfolio scientific teams to ensure clinical input is incorporated at the start of the drug development process, and preclinical insights are translated into the clinical design
• Collaborate with AI and Computational Biology teams to identify, create and utilize innovative tools for analysis of biomarker and translational datasets, accelerate diagnostic advances and explore new approach methodologies (NAMs).
• Serve as a key contributor to the translational sections of clinical and regulatory documents including INDs, IBs, clinical protocols, lab manuals, and briefing books.
• Collaborate across internal and external stakeholders to represent and communicate the translational strategy.
• Oversee and manage external CROs to ensure on time and robust data delivery

Job description

Isomorphic Labs in Cambridge, MA seeks an Associate Director of Translational Medicine to lead strategy for oncology programs and drive biomarker and diagnostic initiatives. You will shape clinical trial design, collaborate across functions, and manage external partners to deliver robust translational data.

The role emphasizes AI-driven tools, cross-disciplinary leadership, and regulatory-experiential contributions to INDs, protocols, and briefing books, with a fast-paced, collaborative culture.