Lead Translational Computational Biologist, Oncology Spatial

Scorpion Therapeutics; Cambridge (MA); Hybrid; USD 150,000 - 210,000; Full time

Job summary

Bristol Myers Squibb seeks a Principal Scientist, Translational Computational Biology to join the Oncology Translational IPS team in Cambridge, MA. The role focuses on embedding computational expertise across discovery through early clinical development, driving data integration and hypothesis generation.

You will lead multimodal analyses, advance AI-enabled methods, mentor scientists, and collaborate across disciplines to shape biomarker strategies and target validation in oncology.

Qualifications

• Ph.D. in computational biology, bioinformatics, or related field with 4+ years relevant experience.
• Strong programming skills in R and Python.
• Experience with spatial biology platforms (Xenium, Visium, COMET, PhenoCycler).
• Familiarity with oncology drug development and biomarker strategies.
• Proven ability to translate complex data into actionable insights.
• Expertise in spatial transcriptomics and proteomics, AI/ML applications in translational science.
• Experience in oncology translational research or early clinical development.
• Publication record in methods development.

Responsibilities

• Analyze multimodal patient-derived datasets including spatial transcriptomics, spatial proteomics, RNA-seq, WES, ctDNA, TCR-seq, and flow cytometry.
• Support biomarker and patient stratification strategies.
• Interpret data to inform target validation, IND-enabling studies, and early clinical decisions.
• Develop and deploy AI-enabled methods for evidence integration and hypothesis generation.
• Lead computational ownership of spatial biology platforms.
• Mentor junior scientists and enhance portfolio capabilities through scalable, reproducible workflows.

Skills

R/Python

Spatial biology platforms

Oncology translational

Data integration

Education

Ph.D. in computational biology or related field

Tools

Xenium

Visium

COMET

PhenoCycler

Job description

Bristol Myers Squibb seeks a Principal Scientist, Translational Computational Biology to join the Oncology Translational IPS team in Cambridge, MA. The role focuses on embedding computational expertise across discovery through early clinical development, driving data integration and hypothesis generation.

You will lead multimodal analyses, advance AI-enabled methods, mentor scientists, and collaborate across disciplines to shape biomarker strategies and target validation in oncology.