Associate Director, Quantitative Pharmacology & Pharmacometrics - Mechanistic Modeling, Immunology

Scorpion Therapeutics; South San Francisco (CA); Hybrid; USD 180,000 - 240,000; Full time

Job summary

Scorpion Therapeutics seeks an Associate Director focused on mechanistic modeling and quantitative drug development within immunology to support translational research and clinical programs.

The role designs model analysis plans, integrates preclinical and clinical data via PK/PD, PBPK, QSP, and other models to optimize development, inform dose selection, trial design, and key decisions. Collaboration with teams and vendors is essential; emphasis on innovative modeling and clear communication.

Qualifications

• Ph.D./PharmD/MS with relevant experience in biopharmaceutics or pharmacometrics
• Proficiency in pharmacometric software (Phoenix, R, NONMEM, etc.)
• Strong mathematical, experimental design, and data analysis skills

Responsibilities

• Design and execute model analysis plans.
• Integrate preclinical and clinical data using PK/PD, PBPK, QSP and other models to optimize drug development.
• Inform dose selection, trial design, and decision-making with modeling outcomes.
• Collaborate with cross-functional teams and external vendors.
• Develop innovative modeling strategies and communicate findings clearly.

Skills

Biopharmaceutics

Pharmacometric research

Mathematical modeling

Data analysis

Communication

Education

Ph.D. in biopharmaceutics/pharmacometrics

PharmD

MS in quantitative sciences

Tools

Phoenix

R

NONMEM

Job description

Role:

Associate Director specializing in mechanistic modeling and quantitative drug development within immunology, supporting translational research and clinical programs.

Responsibilities:

design and execute model analysis plans, integrate preclinical and clinical data using PK/PD, PBPK, QSP, and other models to optimize drug development, inform dose selection, trial design, and decision-making; collaborate with cross-functional teams and external vendors; develop innovative modeling strategies and communicate scientific findings effectively.

Qualifications:

Ph.D. (4+ years relevant), PharmD (6+ years), or MS (8+ years) with expertise in biopharmaceutics, pharmacometrics, or quantitative sciences; proficiency in pharmacometric software (Phoenix, R, NONMEM, etc.); strong mathematical, experimental design, and data analysis skills; excellent communication and collaboration abilities.

Preferred:

track record of impactful model-based drug development, knowledge of immunology, experience with biologics and complex therapeutics, and integration of AI/ML methods.

High-Value:

immunology, biologics, biologics, early to late-stage clinical development, model-based decision support, cross-disciplinary collaboration, hybrid work environment, 10% travel.