Associate Director, Mechanistic PK/PD Modeling

MSD; South San Francisco (CA); Hybrid; USD 157,000 - 247,000; Full time

Job summary

MSD is seeking an Associate Director to lead mechanistic modeling for translational drug development in immunology. You will independently design model analysis plans and collaborate with cross-functional teams to optimize dosing strategies and support clinical trial design.

The role emphasizes developing PK/PD, PBPK, and QSP models, integrating preclinical and clinical data, and communicating complex results clearly to stakeholders. Hybrid work arrangements are available in California.

Qualifications

• Ph.D. or equivalent degree with at least 4 years of relevant experience; PharmD or equivalent degree with at least 6 years; or MS with at least 8 years.
• Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, mathematics, statistics/biostatistics, computational biology/chemistry, or chemical/biomedical engineering.
• Experience in PK/PKPD/QSP modeling using Phoenix, R, Matlab, NONMEM, Monolix.
• Advanced skills in experimental design, mathematical problem solving, data analysis and interpretation.
• Proficiency in written and verbal communication and interdisciplinary collaboration.

Responsibilities

• Apply quantitative skills to integrate preclinical and clinical data for PK/PD, PBPK, QSP, or other mechanistic models.
• Develop and implement translational PK/PD strategies and perform clinical trial simulations.
• Inform dose selection, schedule, and trial design through model-based analyses.

Skills

Data Analysis

Data Modeling

Data Visualization

Drug Development

Immunology Research

Machine Learning (ML)

Model Development

Pharmacology

Pharmacometrics

PKPD Modeling

Quantitative Models

Scientific Presentations

Job description

MSD is seeking an Associate Director to lead mechanistic modeling for translational drug development in immunology. You will independently design model analysis plans and collaborate with cross-functional teams to optimize dosing strategies and support clinical trial design.

The role emphasizes developing PK/PD, PBPK, and QSP models, integrating preclinical and clinical data, and communicating complex results clearly to stakeholders. Hybrid work arrangements are available in California.