Associate Director, LNP Manufacturing & Scale-Up

Flagship Pioneering, Inc.; Cambridge (MA); On-site; USD 154,000 - 204,000; Full time

Job summary

Serif Biomedicines is seeking an Associate Director to lead a team of scientists and engineers in building the next generation of Programmable Medicines. The role requires strong scientific leadership, deep domain experience in lipid nanoparticle manufacturing and scale-up, and a passion for mentoring in a fast-paced entrepreneurial environment.

You will drive LNP scale-up from small R&D formulations to NHP scale, lead upstream and downstream process development, and partner across functions to

Qualifications

• Ph.D. in chemistry, chemical engineering, biochemistry, or biomedical engineering with industry experience.
• Hands-on experience scaling nucleic acid LNP formulations across upstream, downstream, and analytics.
• Knowledge of mixing platforms (T-mix, impingement, microfluidics) and TFF.
• Familiar with LNP analytical methods (DLS, HPLC/CAD, LC-MS, encapsulation assays).
• Solid understanding of lipid and LNP design principles and their impact on product attributes.
• General understanding of molecular biology and nucleic acid therapeutics.
• Experience managing and mentoring research associates and junior scientists.

Responsibilities

• Lead LNP scale-up from small R&D formulations to NHP scale in support of a development candidate.
• Drive upstream and downstream process development, including mixing platforms and filtration.
• Scale targeted LNPs (tLNPs), including conjugation, purification, and analytics.
• Run micro- to mid-scale formulation on microfluidics platforms to support platform advancement.
• Integrate QC profiling and method development (DLS, HPLC/CAD, LC-MS) into process development.
• Lead and mentor a team of scientists and engineers, collaborating across departments for in vivo studies.

Skills

LNP formulation scaling

Process development

Microfluidics

Analytical methods

Team leadership

Molecular biology

Education

PhD in chemistry or related field

Tools

T-mix

impingement

microfluidics

TFF

DLS

HPLC

LC-MS

Job description

Serif Biomedicines is seeking an Associate Director to lead a team of scientists and engineers in building the next generation of Programmable Medicines. The role requires strong scientific leadership, deep domain experience in lipid nanoparticle manufacturing and scale-up, and a passion for mentoring in a fast-paced entrepreneurial environment.

You will drive LNP scale-up from small R&D formulations to NHP scale, lead upstream and downstream process development, and partner across functions to