Associate Director, Expression Sciences — HTS Protein Leader

Johnson & Johnson Innovation; Spring House (PA); On-site; USD 210,000 - 290,000; Full time

Job summary

Johnson & Johnson's Innovative Medicine team in Spring House, PA is seeking an Associate Director, Expression Sciences to lead recombinant protein expression programs across bacterial, insect, and mammalian systems, including scale-up and HT screening for assay development.

You will shape strategy, mentor a team, partner with Protein Chemistry and Structural Biology, drive automation, AI/ML tools, and ensure data integrity while advancing the portfolio.

Qualifications

• Ph.D. in Biochemistry, Molecular Biology, Structural Biology, Chemical Engineering, or related field with 10+ years industry experience.
• Hands-on recombinant protein expression across multiple heterologous systems (E. coli, insect, mammalian).
• Experience designing HT expression screening campaigns and automation platforms.

Responsibilities

• Lead and develop a team of scientists in high-throughput expression screening.
• Define strategic HT expression platform vision and automation roadmap.
• Design screening strategies for soluble and membrane protein targets.
• Drive automation and data quality with LIMS and robotics.
• Collaborate with Protein Chemistry, Structural Biology, and Therapeutic Area teams.
• Manage external vendor/CRO relationships for expression production.
• Ensure EHS, ELN compliance and documentation standards.

Skills

Protein expression

HT screening

Automation/Lab robotics

People management

Cross-functional collaboration

Technical communication

Vendor management

Membrane protein expression

Education

Ph.D. in Biochemistry or related field

Tools

Automation platforms (Tecan, Hamilton)

LIMS

Cell-free systems

Job description

Johnson & Johnson's Innovative Medicine team in Spring House, PA is seeking an Associate Director, Expression Sciences to lead recombinant protein expression programs across bacterial, insect, and mammalian systems, including scale-up and HT screening for assay development.

You will shape strategy, mentor a team, partner with Protein Chemistry and Structural Biology, drive automation, AI/ML tools, and ensure data integrity while advancing the portfolio.