Senior Scientist, Bioconjugates, Downstream Processing

6084-Janssen Research & Development, LLC Legal Entity; Malvern (Chester County); On-site; USD 150,000 - 190,000; Full time

Job summary

Johnson & Johnson is seeking a Senior Scientist, Bioconjugates, Downstream Processing in Malvern, PA. The role leads process development for antibodies and bioconjugates, including tLNP, ADC, AOC, and APC within the API-Large Molecule group.

Responsibilities include experimental design, data analysis, and technology transfers. Requirements include a PhD with 3+ years post-doctoral experience or MS with 12+ years or BS with 15+ years, plus hands-on experience in downstream processing,

Qualifications

• PhD with 3+ years post-doctoral experience OR MS with 12+ years OR BS with 15+ years in relevant field.
• Laboratory experience in downstream processing, antibody/recombinant protein purification, and bioconjugate production is required.
• Experience with chromatography, filtration, and conjugation is essential.
• Strong data recording, reporting, and collaboration skills are expected.

Responsibilities

• Lead experimental design and optimize processes for target scale including conjugation, chromatography, and TFF.
• Design development studies to set parameter ranges for chromatography, filtration, and conjugation steps.
• Record, analyze, and summarize data; prepare technical documents and support technology transfers.
• Collaborate in a team and manage multiple projects to meet timelines.

Skills

Biochemistry

Chemistry

CMC

Analytical Reasoning

Data Analysis

Education

PhD in Chemical Engineering/Biological Sciences/Biochemistry

MS in Chemical Engineering/Biological Sciences/Biochemistry

BS in Chemical Engineering/Biological Sciences/Biochemistry

Job description

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

Job Function: Discovery & Pre-Clinical/Clinical Development

Job Sub Function: Biotherapeutics R&D

Job Category: Scientific/Technology

All Job Posting Locations: Pennsylvania (Any City)

Job Description

About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine

Purpose

The Senior Scientist, Bioconjugates, Downstream Processing leads and performs process development activities for antibodies and bioconjugates such as targeted lipid-nano particles (tLNP), antibody-drug conjugate (ADC), antibody-oligo conjugate (AOC), and antibody-peptide conjugate (APC) within the API-Large Molecule group in Malvern, PA.

You will be responsible for:

• Lead and participate in experimental design, execute planned experiments, and optimize process steps for the target process scale, including laboratory- and occasional pilot-scale conjugation reactions, chromatography, and TFF filtration.
• Lead the design and execution of development studies to identify appropriate conditions and establish ranges for critical process parameters across chromatography, filtration, and conjugation reaction process steps.
• Record and analyze experimental data, verify data integrity and accuracy, report and summarize findings for the project team, draft technical documents, and perform technology transfers to collaboration partners.
• Work collaboratively in a team environment and contribute independently to meet project timelines and objectives.

Qualifications / Requirements

PhD (preferably in Chemical Engineering or Biological Sciences or Biochemistry or other equivalent major) with at least 3 years of relevant post-doctoral experience OR MS (Preferably in Chemical Engineering or Biological Sciences or Biochemistry or other equivalent major) and with at least 12 years of relevant experience OR a BS (preferably in Chemical Engineering or Biological Sciences or Biochemistry or other equivalent major) and with at least 15 years of relevant experience is required.

Knowledge and hands-on laboratory experience in downstream processing, purification of antibodies/recombinant protein therapeutics, and production of bioconjugates (such as tLNP, ADC or other equivalent conjugates), in particular chromatography, filtration and conjugation, are required.

Exposure to analytical method development for in-process methods is preferred.

The candidate must be highly organized and capable of managing/pursuing multiple projects independently. Good written and verbal communication skills are required. Experience maintaining written records of work in the form of (electronic) notebooks, technical reports and protocols is required. Data reporting, ability to present findings to management, and experience with team-based collaborations is a must. Occasional weekend work may be required.

Equal Opportunity Employer Statement

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law.

We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers , internal employees contact AskGS to be directed to your accommodation resource.

Required Skills

Analytical Reasoning, Biochemistry, Chemistry, Manufacturing, and Control (CMC), Coaching, Consulting, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Pharmacogenetics, Pharmacovigilance, Process Improvements, Quality Assurance (QA), Relationship Building, Research Documents, Scientific Research, Technologically Savvy

Preferred Skills

Analytical Reasoning, Biochemistry, Chemistry, Manufacturing, and Control (CMC), Coaching, Consulting, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Pharmacogenetics, Pharmacovigilance, Process Improvements, Quality Assurance (QA), Relationship Building, Research Documents, Scientific Research, Technologically Savvy