Associate Director, Clinical Pharmacometrics (Remote)

Dianthus Therapeutics, Inc.; Waltham (MA); On-site; USD 140,000 - 230,000; Full time

Job summary

Dianthus Therapeutics, Inc. seeks a senior quantitative pharmacology scientist to lead QSP, PopPK and exposure–response analyses across autoimmune programs.

You will design and execute models to inform FIH dose selection and Phase 2 planning, translating complex results for cross-functional decision-making and regulatory teams. The role requires deep MATLAB, NONMEM, and R expertise, with a proven track record of model-based drug development and collaboration across Clinical Development,

Qualifications

• Ph.D. in Pharmacometrics or related field.
• Minimum 6–8 years of industry experience in clinical pharmacology/pharmacometrics with hands-on modeling ownership.
• Proficiency in QSP modeling using MATLAB and modules such as SimBiology or equivalent.
• Strong hands-on expertise in population PK/PD modeling using NONMEM with data handling, diagnostics and simulation.
• Proficiency in R for pharmacometric data analysis, visualization, and reporting.
• Experience translating nonclinical and early clinical data into human dose projections and Phase 2 dosing strategies.

Responsibilities

• Develop and apply QSP models to characterize target engagement, RO, PK/PD relationships and disease biology in autoimmune programs.
• Lead population PK/PD and exposure–response analyses across SAD/MAD data.
• Translate modeling findings into Phase 2 dose recommendations for regulatory submissions.
• Collaborate with cross-functional teams to align quantitative strategy with program milestones.
• Oversee CRO pharmacometricians and contribute to department-wide methodological improvements.
• Prepare pharmacometric sections of regulatory submissions and briefing materials.

Skills

QSP modeling

NONMEM

R programming

MATLAB

SimBiology

Dose-response analysis

Cross-functional collaboration

Education

Ph.D. in Pharmacometrics or related field

Tools

MATLAB

NONMEM

R

SimBiology

Job description

Dianthus Therapeutics, Inc. seeks a senior quantitative pharmacology scientist to lead QSP, PopPK and exposure–response analyses across autoimmune programs.

You will design and execute models to inform FIH dose selection and Phase 2 planning, translating complex results for cross-functional decision-making and regulatory teams. The role requires deep MATLAB, NONMEM, and R expertise, with a proven track record of model-based drug development and collaboration across Clinical Development,