Associate Director, Quantitative Pharmacology and Pharmacometrics, Cardiometabolic

Scorpion Therapeutics; Boston (MA); On-site; USD 180,000 - 240,000; Full time

Job summary

Scorpion Therapeutics is seeking a senior modeling scientist to lead quantitative pharmacometrics efforts in Boston. You will develop model-based strategies across translational PK/PD, population PK/PD, and trial simulations to inform dose selection and trial design.

You will partner with discovery, development, regulatory, and external vendors to implement model-informed decisions and communicate results across teams. Strong collaboration and regulatory knowledge are essential.

Qualifications

• PhD/PharmD/MS with proven independence in drug development or regulatory settings.
• Strong background in PK/PD and quantitative modeling.
• Experience with population PK/PKPD analyses using listed tools.

Responsibilities

• Develop model-based strategies for translational PK/PD and clinical trial simulations.
• Represent QP2 on discovery and clinical teams with quantitative approaches.
• Collaborate with vendors and partners to align model-informed decisions.
• Design studies, interpret data, and communicate results clearly.
• Maintain knowledge of regulatory expectations and support submissions.
• Provide modeling input and interpretation with pharmacometrics colleagues.

Skills

BI

Data Modeling

Data Science

Data Visualization

Machine Learning

Software Development

Stakeholder Mgmt

Waterfall

Education

Ph.D. in relevant field

PharmD

MS in quantitative discipline

Biopharmaceutics/Pharmacometrics education

Tools

R

Matlab

Phoenix

NONMEM

Monolix

Job description

Responsibilities:

• Develop and apply model-based strategies (translational PK/PD, mechanistic models, population PK/PD, and clinical trial simulations) to support quantitative decision-making (dose selection, trial design, go/no-go).
• Represent QP2 on cardiometabolic discovery, early, and late clinical development teams using quantitative approaches.
• Partner with functional colleagues, external vendors, and strategic partners to build aligned, quantitative, model-informed approaches for drug discovery, development, and regulatory decisions.
• Collaborate across disciplines on study design, protocol development, execution, data interpretation, reporting, and results communication.
• Maintain knowledge of global regulatory expectations and contribute to regulatory document development and submission defense.
• Provide modeling input with pharmacometrics colleagues (strategies, analyses, interpretation, reporting).

Qualifications (Required):

• Ph.D. (4+ years), PharmD (6+ years), or MS (8+ years) in relevant field; increasing responsibility/independence in drug development, regulatory agency, or academia.
• Education in biopharmaceutics/pharmaceutical sciences/pharmacometrcs/chemical or biomedical engineering (or related quantitative discipline).
• Experience with population PK and PK/PD analyses using R, Matlab, Phoenix, NONMEM, Monolix, or similar tools.
• Strong written and verbal communication; ability to collaborate and plan complex work.
• Knowledge of modeling complex therapeutics and mechanistic modeling/QSP.

Preferred:

• Knowledge of cardiometabolic clinical drug development programs.
• Advanced math problem-solving, data analysis/interpretation, experimental design, and statistics.
• Understanding of biopharmaceutical/ADME properties of small molecules and/or biologics.
• Proven impact advancing decisions via model-based approaches.

Skills (Required):

• BI, Data Modeling, Data Science, Data Visualization, Machine Learning (ML), Software Development, Stakeholder Relationship Management, Waterfall Model.