Associate Director, Quantitative System Pharmacology (QSP)

Scorpion Therapeutics; Waltham (MA); Hybrid; USD 140,000 - 210,000; Full time

Job summary

Scorpion Therapeutics seeks an Associate Director, Quantitative System Pharmacology (QSP) to advance Model-informed Drug Development across preclinical, translational, and clinical phases for autoimmune and inflammation biologics.

You will develop and execute fit-for-purpose QSP and (m)PBPK models, support simulations, and collaborate with biology, chemistry, and pharmacology teams to accelerate program progression and clearly communicate modeling insights.

Qualifications

• PhD with 6+ years in QSP, PBPK or related fields.
• Hands-on proficiency in MATLAB/SimBiology, R, GastroPlus or similar software.
• Experience with therapeutic antibodies and biologics in preclinical, translational, and clinical pharmacology.

Responsibilities

• Develop and execute QSP and (m)PBPK models for autoimmune/inflammation programs.
• Support simulation efforts and model-informed decision making.
• Collaborate with biology, chemistry and pharmacology teams to accelerate programs.
• Communicate modeling insights to cross-functional teams and leadership.

Skills

QSP modeling

MIDD

MATLAB/SimBiology

R

GastroPlus

Biologics

Education

PhD in Pharmacology/Pharm Sci or related field

Tools

MATLAB/SimBiology

R

GastroPlus

Job description

Role

Role: Associate Director, Quantitative System Pharmacology (QSP), contributing to Model-informed Drug Development (MIDD) strategies across preclinical, translational, and clinical phases for autoimmune and inflammation biologics.

Responsibilities

Responsibilities: develop and execute fit-for-purpose QSP and (m)PBPK models, support simulation efforts, collaborate with cross-functional teams (biology, chemistry, pharmacology), and communicate modeling insights to accelerate program progression.

Qualifications

Qualifications: PhD with 6+ years in QSP, (m)PBPK, or related fields, with hands-on proficiency in MATLAB/Simbiology, R, GastroPlus, or similar software. Experience with therapeutic antibodies and biologics is essential, with demonstrated success in preclinical, translational, and clinical pharmacology.

High-value specifics

High-value specifics: focus on autoimmune/inflammation indications, biologics modalities, and mechanistic modeling support.

Work setup

Work setup: hybrid in Waltham, MA, or remote with travel to headquarters as needed. The role requires strong communication skills, proactive mindset, attention to detail, and ability to work in a fast-paced environment.