Assistant Lead, TCR Discovery & Translational Research

Weill Cornell Medicine; New York (NY); Vor Ort; USD 129.000 - 146.000; Vollzeit

Zusammenfassung

Weill Cornell Medicine in New York seeks an Assistant Lead, TCR Discovery Team to drive a high-throughput discovery engine for tumor-specific TCRs, supporting downstream engineering and translational development.

The role requires a PhD with 8+ years post-PhD in immunology or related field, experience in TCR discovery and preclinical development, and ability to lead cross-functional teams. The position is on-site in NYC with required flexible hours.

Qualifikationen

• 8+ years post-PhD experience in academia or industry.
• Prior experience in TCR discovery, complex immune assays and preclinical development is required.
• Experience working across functional teams.

Aufgaben

• Design and implement end-to-end personalized TCR discovery workflow, including tumor-reactive T cell identification, TCR cloning and characterization.
• Design and implement advanced de-risking methods and workflows to assess alloreactivity, unintended HLA interactions, off-target toxicity risk including X-scan, peptide library screens and library-on-library HTS.
• Interpret and report complex campaigns for identification of TCRs against known tumor antigens.
• Integrate data across functional potency, specificity, and safety to support go/no-go decisions on specific TCRs, their cloning, specificity validation, and safety de-risking.
• Prepare translational packages (reports, assay descriptions, validation summaries) supporting IND/CTA-enabling preclinical data.
• Collaborate with cross functional teams to integrate learnings and advance gene therapy initiatives.
• Operate with highest integrity and ethics, conduct all experiments following lab, department, and college policies and procedures.
• Mentor and train junior scientists and staff, promote scientific rigor, collaboration, independent thinking, and career advancement.
• Prepare scientific abstracts and articles, publish results in research journals, and present findings at conferences

Kenntnisse

High-throughput TCR discovery

TCR cloning

Functional validation

Safety de-risking

Cross-functional collaboration

Scientific communication

Ausbildung

PhD in Immunology, Molecular/Cell Biology, Genetic Engineering or related field

Jobbeschreibung

Weill Cornell Medicine in New York seeks an Assistant Lead, TCR Discovery Team to drive a high-throughput discovery engine for tumor-specific TCRs, supporting downstream engineering and translational development.

The role requires a PhD with 8+ years post-PhD in immunology or related field, experience in TCR discovery and preclinical development, and ability to lead cross-functional teams. The position is on-site in NYC with required flexible hours.