Analytical Genomics Scientist for Engineered Cell Therapies

sanabiotech; Cambridge (MA); On-site; USD 130,000 - 160,000; Full time

Job summary

Sana Biotechnology is seeking a lab-based Scientist, Analytical Genomics, to help advance Type 1 Diabetes and in vivo CAR‑T programs by turning molecular and genomics assays into decision‑ready data. You will report to the Director, Analytical Genomics and collaborate to support Research, CMC, Clinical, and IND‑enabling decisions.

The role involves developing and applying genomic assays, managing sample processing, libraries, sequencing, and data interpretation, with an emphasis on

Qualifications

• PhD in molecular biology, biochemistry, genomics, or related field with 2+ years of relevant industry experience, or MS with 7+ years of relevant industry experience.
• 4+ years of hands‑on molecular biology experience, including nucleic acid extraction, quantification/QC, NGS library preparation, Illumina sequencing, ddPCR/RT‑ddPCR, and qPCR.
• Experience developing, optimizing, troubleshooting, and qualifying molecular or genomics assays for engineered cell and gene therapy products.
• Experience with assay qualification, SOPs, regulatory‑aligned documentation, and electronic systems such as Benchling or Veeva.
• Ability to analyze, interpret, document, and communicate genomic assay results with Computational, Research, CMC, Clinical, and program teams.

Responsibilities

• Develop, optimize, and qualify molecular and genomics assays to characterize engineered cell and gene therapy products.
• Apply genomic technologies and molecular workflows, including on- and off-target editing assessment, genome integrity and stability assessment, single-cell and spatial transcriptomics, ddPCR, RT-ddPCR, and qPCR.
• Develop reference materials and define assay controls, QC metrics, acceptance criteria, and performance measures.
• Execute core laboratory workflows, including sample processing, nucleic acid extraction, library preparation, sequencing, and assay troubleshooting.
• Generate, review, analyze, interpret and communicate genomic data with Computational Biology, Computational Engineering, and cross‑functional partners to support Research, CMC, Clinical, and IND‑enabling program decisions.
• Support molecular and genomic method qualification, SOP development, and regulatory‑aligned documentation for GxP activities and regulatory submissions.
• Maintain accurate, traceable, and audit‑ready records of sample tracking, metadata, experimental procedures, assay results, and study reports in Benchling and Veeva.
• Maintain Genomics Lab readiness by supporting inventory control, equipment maintenance, reagent tracking, sample and material shipments, and CRO coordination.

Skills

Molecular biology

NGS library prep

qPCR/ddPCR

Data interpretation

Scientific communication

Education

PhD in molecular biology/biochemistry/genomics

MS with 7+ years experience

Tools

Benchling

Veeva

Hamilton

KingFisher

Job description

Sana Biotechnology is seeking a lab-based Scientist, Analytical Genomics, to help advance Type 1 Diabetes and in vivo CAR‑T programs by turning molecular and genomics assays into decision‑ready data. You will report to the Director, Analytical Genomics and collaborate to support Research, CMC, Clinical, and IND‑enabling decisions.

The role involves developing and applying genomic assays, managing sample processing, libraries, sequencing, and data interpretation, with an emphasis on