Scientist, Analytical Genomics

sanabiotech; Cambridge (MA); On-site; USD 130,000 - 160,000; Full time

Job summary

Sana Biotechnology is seeking a lab-based Scientist, Analytical Genomics, to help advance Type 1 Diabetes and in vivo CAR‑T programs by turning molecular and genomics assays into decision‑ready data. You will report to the Director, Analytical Genomics and collaborate to support Research, CMC, Clinical, and IND‑enabling decisions.

The role involves developing and applying genomic assays, managing sample processing, libraries, sequencing, and data interpretation, with an emphasis on

Qualifications

• PhD in molecular biology, biochemistry, genomics, or related field with 2+ years of relevant industry experience, or MS with 7+ years of relevant industry experience.
• 4+ years of hands‑on molecular biology experience, including nucleic acid extraction, quantification/QC, NGS library preparation, Illumina sequencing, ddPCR/RT‑ddPCR, and qPCR.
• Experience developing, optimizing, troubleshooting, and qualifying molecular or genomics assays for engineered cell and gene therapy products.
• Experience with assay qualification, SOPs, regulatory‑aligned documentation, and electronic systems such as Benchling or Veeva.
• Ability to analyze, interpret, document, and communicate genomic assay results with Computational, Research, CMC, Clinical, and program teams.

Responsibilities

• Develop, optimize, and qualify molecular and genomics assays to characterize engineered cell and gene therapy products.
• Apply genomic technologies and molecular workflows, including on- and off-target editing assessment, genome integrity and stability assessment, single-cell and spatial transcriptomics, ddPCR, RT-ddPCR, and qPCR.
• Develop reference materials and define assay controls, QC metrics, acceptance criteria, and performance measures.
• Execute core laboratory workflows, including sample processing, nucleic acid extraction, library preparation, sequencing, and assay troubleshooting.
• Generate, review, analyze, interpret and communicate genomic data with Computational Biology, Computational Engineering, and cross‑functional partners to support Research, CMC, Clinical, and IND‑enabling program decisions.
• Support molecular and genomic method qualification, SOP development, and regulatory‑aligned documentation for GxP activities and regulatory submissions.
• Maintain accurate, traceable, and audit‑ready records of sample tracking, metadata, experimental procedures, assay results, and study reports in Benchling and Veeva.
• Maintain Genomics Lab readiness by supporting inventory control, equipment maintenance, reagent tracking, sample and material shipments, and CRO coordination.

Skills

Molecular biology

NGS library prep

qPCR/ddPCR

Data interpretation

Scientific communication

Education

PhD in molecular biology/biochemistry/genomics

MS with 7+ years experience

Tools

Benchling

Veeva

Hamilton

KingFisher

Job description

About the role

Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who are passionate about delivering the possible to patients, and who lead with the desire to work on novel ideas. As a lab-based Scientist, Analytical Genomics, you will report to the Director, Analytical Genomics to help advance Sana's Type 1 Diabetes and in vivo CAR‑T programs by turning molecular and genomics assays into meaningful, decision‑ready data.

What you'll do

• Develop, optimize, and qualify molecular and genomics assays to characterize engineered cell and gene therapy products.
• Apply genomic technologies and molecular workflows, including on- and off-target editing assessment, genome integrity and stability assessment, single-cell and spatial transcriptomics, ddPCR, RT-ddPCR, and qPCR.
• Develop reference materials and define assay controls, QC metrics, acceptance criteria, and performance measures.
• Execute core laboratory workflows, including sample processing, nucleic acid extraction, library preparation, sequencing, and assay troubleshooting.
• Generate, review, analyze, interpret and communicate genomic data with Computational Biology, Computational Engineering, and cross‑functional partners to support Research, CMC, Clinical, and IND‑enabling program decisions.
• Support molecular and genomic method qualification, SOP development, and regulatory‑aligned documentation for GxP activities and regulatory submissions.
• Maintain accurate, traceable, and audit‑ready records of sample tracking, metadata, experimental procedures, assay results, and study reports in Benchling and Veeva.
• Maintain Genomics Lab readiness by supporting inventory control, equipment maintenance, reagent tracking, sample and material shipments, and CRO coordination.

What we're looking for

• PhD in molecular biology, biochemistry, genomics, or related field with 2+ years of relevant industry experience, or MS with 7+ years of relevant industry experience.
• 4+ years of hands‑on molecular biology experience, including nucleic acid extraction, quantification/QC, NGS library preparation, Illumina sequencing, ddPCR/RT‑ddPCR, and qPCR.
• Experience developing, optimizing, troubleshooting, and qualifying molecular or genomics assays for engineered cell and gene therapy products.
• Experience with assay qualification, SOPs, regulatory‑aligned documentation, and electronic systems such as Benchling or Veeva.
• Ability to analyze, interpret, document, and communicate genomic assay results with Computational, Research, CMC, Clinical, and program teams.

What will separate you from the crowd

• Hands‑on experience with on- and off‑target editing assays, genomic integrity, and biodistribution that support cell and gene therapy programs.
• Experience applying single‑cell, spatial transcriptomics, multiomics or other advanced genomics workflows to answer complex biological or product‑characterization questions.
• Experience implementing automated sample preparation and assay execution platforms such as Hamilton, KingFisher, or similar systems.
• Strong understanding of regulatory expectations for genomics assays, including analytical method qualification, GxP documentation, lab compliance, and IND‑enabling support.
• Ability to translate complex genomic assay data into clear, decision‑ready summaries for Research, CMC, Clinical, and regulatory stakeholders.

What you should know

This role may require occasional evening or weekend work to support critical project deliverables.

The role includes standard laboratory activities such as standing, walking, sitting, using hands and arms, lifting or carrying up to 10 lbs, and occasional reaching, pushing, pulling, crouching, kneeling, twisting, or squatting.

The base pay range for this position at commencement of employment is expected to be between $130,000 and $160,00/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job‑related knowledge, skills, and experience.

How we work together for patients

• Lead from every seat - we seek to understand, act with honesty, and engage in the crucial conversations
• Thrive as a team - we hire amazing people, are intensely curious, and cultivate inclusion and personal connectivity
• Make it happen - we value vigorous debate, alignment around our decisions, and resilient execution

Get to know us

At Sana, we believe that a workforce with varied backgrounds strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many