AI Principal Engineer: Generative & Clinical Data Analytics

Exelixis Inc; Alameda (CA); On-site; USD 172,000 - 245,000; Full time

Benefits offered by this job

401(k) plan

Medical, dental, vision

Life and disability insurance

Stock purchase program

Vacation and holidays

Discretionary bonus

Job summary

Exelixis Inc in Alameda is seeking an AI Principal Engineer - Clinical Data Analytics to lead building and scaling data engineering, AI capabilities, and Generative AI across the Development organization. You will own data architecture, governance, and cloud-native patterns to enable analytics, ML, and Generative AI in a regulated environment.

The role blends hands-on technical depth with governance, platform reliability and cross‑functional collaboration.

Qualifications

• Bachelor's or Master's degree in Computer Sciences, Data or related field with substantial experience in data analytics.
• Advanced experience with Databricks, Unity Catalog, Delta Lake and lakehouse governance.
• Advanced proficiency in Python and SQL; working knowledge of R if needed.

Responsibilities

• Develop production AI/ML and Generative AI solutions, including deployment, monitoring and lifecycle management.
• Partner with business leaders to identify and deliver high-impact analytics and AI use cases.
• Lead MLOps/LLMOps practices for model deployment, prompt/version management and governance.
• Standardize reusable data models, semantic layers, and APIs for downstream analytics and AI applications.
• Serve as a trusted advisor translating business questions into data and analytics solutions.
• Enable data-driven decision-making through harmonized metrics and KPIs.
• Explain technical concepts to non-technical stakeholders.
• Collaborate with Legal, Compliance and Security to meet regulatory standards.
• Design and evolve data architectures including warehouses, data lakes and pipelines.
• Ensure scalable, reliable and high-performance data platforms in collaboration with IT.

Skills

Databricks

Unity Catalog

Delta Lake

Python

SQL

BI platforms

Spotfire

Tableau

Power BI

AWS Cloud

CI/CD tooling

Data Modeling

Data Governance

GxP compliance

Communication skills

Education

Bachelor's/Master's degree in CS/Data or related field

Tools

Atlan

Collibra

Reltio

Job description

Exelixis Inc in Alameda is seeking an AI Principal Engineer - Clinical Data Analytics to lead building and scaling data engineering, AI capabilities, and Generative AI across the Development organization. You will own data architecture, governance, and cloud-native patterns to enable analytics, ML, and Generative AI in a regulated environment.

The role blends hands-on technical depth with governance, platform reliability and cross‑functional collaboration.