AI Principal Engineer — Clinical Data Analytics & Gen AI

Exelixis, Inc.; Alameda (CA); On-site; USD 172,000 - 245,000; Full time

Benefits offered by this job

401k plan

Medical Insurance

Dental Insurance

Vision Insurance

Life Insurance

Disability Insurance

Flexible Spending Accounts

Discretionary bonus

Stock options

Paid time off

Holidays

Job summary

Exelixis, Inc. seeks an AI Principal Engineer to lead clinical data analytics, building scalable AI and data platforms in a regulated environment. You will own data architecture, governance, and cloud-native patterns across Data Science and Statistics, delivering actionable insights and AI capabilities including Generative AI.

You will drive MLOps, standardized data models, and enterprise governance while partnering with business leaders to deliver high-impact analytics across clinical domains.

Qualifications

• Advanced experience with Databricks, Unity Catalog, Delta Lake and lakehouse governance.
• Proficient in Python and SQL; R is a plus.
• Experience leading data acquisition, analytics, and AI across clinical domains.
• Knowledge of metadata management and data lineage tracking in Unity Catalog.
• Enterprise data governance and data cataloging tools experience.
• BI platform development with Spotfire, Tableau and Power BI.
• SaaS AWS Cloud infrastructure expertise: EC2, Lambda, Glue, Redshift.
• CI/CD tooling and version control in data pipelines.
• Data modeling, warehouse architecture, and data integration.
• Pharmaceutical/CRO domain familiarity beneficial.

Responsibilities

• Develop production AI/ML and Generative AI solutions including deployment and lifecycle management.
• Partner with business leaders to identify, scope, prioritize and deliver high-impact analytics and AI use cases.
• Lead MLOps/LLMOps for model deployment, prompt/version management, monitoring and governance.
• Standardize reusable data models, semantic layers, and APIs for downstream analytics and AI applications.
• Serve as trusted advisor to functional leaders, translating business questions into data and analytics solutions.
• Enable timely, data-driven decision-making through harmonized metrics, KPIs and insight frameworks.
• Explain technical concepts to non-technical stakeholders; ensure regulatory and ethical standards.
• Collaborate with Legal, Compliance and Security on AI solutions; design and evolve modern data architectures.

Skills

Python

SQL

AI/ML

Generative AI

MLOps/LLMOps

Data governance

Data modeling

Data pipelines

CI/CD tooling

Version control

Databricks

Unity Catalog

Delta Lake

Tableau

Power BI

Spotfire

AWS Cloud

Redshift

Education

Bachelor's degree in Computer Sciences or related field

Master's degree in Computer Sciences or related field

Tools

Databricks

Unity Catalog

Delta Lake

Redshift

Lambda

Glue

Tableau

Power BI

Spotfire

EC2

SaaS AWS Cloud

Job description

Exelixis, Inc. seeks an AI Principal Engineer to lead clinical data analytics, building scalable AI and data platforms in a regulated environment. You will own data architecture, governance, and cloud-native patterns across Data Science and Statistics, delivering actionable insights and AI capabilities including Generative AI.

You will drive MLOps, standardized data models, and enterprise governance while partnering with business leaders to deliver high-impact analytics across clinical domains.