AI-Driven Principal Data Scientist — Clinical Development

Genentech; Boston (MA); On-site; USD 169,100 - 314,000; Full time

Job summary

Genentech in Boston, MA seeks an IA Principal Data Scientist to build and deploy AI/ML‑powered digital tools that transform how medicines are developed. You will collaborate with product managers, software engineers, and UX researchers to design, test, and scale statistical capabilities from clinical and real‑world data.

You will lead scalable, ethical, and compliant data science initiatives, focusing on responsible AI, model deployment, and cross‑functional impact across portfolio strategy and

Qualifications

• Masters or PhD in Data Science, CS, statistics, applied mathematics, bioinformatics, or related field.
• 6+ years applying advanced statistical and ML techniques in biomedical, clinical, or digital health domains.
• Proven track record with model development, simulation studies, and decision-support frameworks.
• Hands-on experience with Python or R, and ML libraries such as scikit‑learn, TensorFlow, PyTorch.
• Experience building pipelines for training, evaluating, and deploying ML solutions in production.
• Expertise with RWD, Bayesian methods, causal inference, or related areas.
• Strong collaboration, communication, and ability to influence in cross-functional teams.

Responsibilities

• Develop and apply advanced statistical and ML methods for integration into tools and software in clinical development and decision‑making support.
• Design and productize execution of simulation studies to evaluate innovative trial designs and statistical frameworks.
• Translate complex scientific and operational considerations into software requirements for model development and usage.
• Independently drive exploratory analysis of complex clinical, biomarker, and operational data to extract insights and develop predictive models.
• Develop scalable, reproducible pipelines for data processing, model training, evaluation, and deployment in regulated environments.
• Optimize model performance, mitigate bias or drift, and develop evaluation approaches for GenAI components.
• Co‑lead architectural design of ML and GenAI systems ensuring traceability, compliance, and explainability.
• Partner with software engineering, product, UX and science teams to integrate models into real‑world applications.
• Contribute to leadership by publishing and presenting novel methodologies in high‑impact venues.

Skills

Advanced statistics

Machine learning

Python

R

Model deployment

Collaboration

Independent thinking

Strategic thinking

Education

Master's or PhD in Data Science/CS/Statistics/Applied Math/Bioinformatics

Tools

Python

R

scikit-learn

TensorFlow

PyTorch

Stan

PyMC

brms

Job description

Genentech in Boston, MA seeks an IA Principal Data Scientist to build and deploy AI/ML‑powered digital tools that transform how medicines are developed. You will collaborate with product managers, software engineers, and UX researchers to design, test, and scale statistical capabilities from clinical and real‑world data.

You will lead scalable, ethical, and compliant data science initiatives, focusing on responsible AI, model deployment, and cross‑functional impact across portfolio strategy and