Single-Cell Transcriptomics Scientist, Biomarker Discovery

MSD INTERNATIONAL GMBH (SINGAPORE BRANCH); Singapore; On-site; SGD 60,000 - 100,000; Full time

Job summary

MSD INTERNATIONAL GMBH (SINGAPORE BRANCH) in Singapore seeks a Postdoctoral Fellow specializing in single-cell transcriptomics to advance target and biomarker discovery in cancer biology. You will design experiments, generate data, and contribute to informing drug discovery decisions.

You will collaborate across data science, biology, and translational pharmacology, publish findings, present at conferences, and develop analytical capabilities for high-dimensional single-cell datasets.

Qualifications

• PhD in cancer biology, molecular/cell biology, functional genomics, or related field.
• Strong publication record in peer-reviewed journals.
• Experience with mammalian cell biology techniques.
• Experience with RNAi and CRISPR perturbation.
• Experience with high-dimensional transcriptomics workflows.
• Strong teamwork and communication skills.

Responsibilities

• Design loss-of-function and gain-of-function perturbation studies using RNAi, CRISPR knockout/activation.
• Characterise perturbation effects with molecular assays (qRT-PCR, immunoassays, etc.).
• Develop high-throughput single-cell RNA-seq workflows for perturbation studies.
• Collaborate with data scientists and biologists to analyze single-cell datasets.
• Develop strategies to uncover disease mechanisms and identify therapeutic targets.
• Communicate results via presentations, publications, posters.

Skills

Scientific publications

Teamwork

Communication

Problem solving

Mammalian cell biology

Molecular biology techniques

RNAi perturbation

CRISPR perturbation

Single-cell transcriptomics

Education

Ph.D. in cancer biology / molecular or cell biology / functional genomics

Tools

RNAi

CRISPR knockout/activation

qRT-PCR

Immunoassays

Western blot

Microscopy

High-content imaging

Single-cell RNA-seq workflows

Job description

MSD INTERNATIONAL GMBH (SINGAPORE BRANCH) in Singapore seeks a Postdoctoral Fellow specializing in single-cell transcriptomics to advance target and biomarker discovery in cancer biology. You will design experiments, generate data, and contribute to informing drug discovery decisions.

You will collaborate across data science, biology, and translational pharmacology, publish findings, present at conferences, and develop analytical capabilities for high-dimensional single-cell datasets.