Senior MSAT Downstream Process Engineer – Scale-Up & GMP

scaleup bio pte. ltd.; Singapore; On-site; SGD 180,000 - 280,000; Full time

Job summary

ScaleUp Bio in Singapore seeks a Senior MSAT Downstream Process Engineer to lead transfer, scale-up, and optimization of downstream operations for fermentation-derived products. You will guide technical execution from pilot to commercial manufacturing, working with Process Engineering, Production, Quality and Customer teams.

The role requires hands-on experience with centrifugation, filtration and chromatography, strong GMP discipline, and the ability to mentor junior engineers while delivering

Qualifications

• Bachelor’s or Master’s degree in Chemical Engineering, Biochemical Engineering, Biotechnology, Bioprocess Engineering or a related discipline.
• Typically 10–20 years of relevant industrial experience in downstream process development, MSAT, process engineering, technology transfer or biomanufacturing.
• Substantial experience within pharmaceutical, enzyme, industrial fermentation, biopharmaceutical or related biotechnology industries.
• Strong hands-on knowledge of fermentation-derived product recovery and purification.
• Experience scaling downstream processes from laboratory or pilot scale into commercial manufacturing.
• Strong understanding of GMP environments, sterile handling, contamination control, cleaning validation and continuous improvement.

Responsibilities

• Lead the technical transfer of customer downstream processes into ScaleUp Bio’s pilot and commercial manufacturing facilities.
• Assess customer process packages, identify technical gaps and translate laboratory-scale protocols into executable manufacturing processes.
• Develop and refine process flow diagrams, mass balances, operating parameters, equipment requirements and scale-up strategies.
• Evaluate process scalability, facility fit, equipment capability and operational risks before manufacturing.
• Design and execute engineering, verification, demonstration and manufacturing runs.
• Provide floor-level technical support during process execution and ensure GMP, food-safety and quality requirements are met.
• Mentor junior and mid-level engineers and collaborate with cross-functional teams.

Skills

Downstream processing

MSAT

Process transfer

Scale-up

GMP

Cross-functional leadership

Troubleshooting

Education

Bachelor’s or Master’s in Chemical/Biochemical/Bioprocess Engineering

Tools

Centrifugation equipment

Microfiltration/Ultrafiltration

Diafiltration

Depth filtration

Hydrophobic interaction chromatography

Ion-exchange chromatography

Affinity chromatography

Spray drying

Freeze drying

Job description

ScaleUp Bio in Singapore seeks a Senior MSAT Downstream Process Engineer to lead transfer, scale-up, and optimization of downstream operations for fermentation-derived products. You will guide technical execution from pilot to commercial manufacturing, working with Process Engineering, Production, Quality and Customer teams.

The role requires hands-on experience with centrifugation, filtration and chromatography, strong GMP discipline, and the ability to mentor junior engineers while delivering