Senior MSAT Downstream Process Leader

SCALEUP BIO PTE. LTD.; Singapore; On-site; SGD 150,000 - 210,000; Full time

Job summary

ScaleUp Bio, a Singapore-based fermentation CDMO, seeks a Senior MSAT Downstream Process Engineer to lead transfer, scale-up and optimisation of downstream operations. You will supervise centrifugation, filtration and chromatography steps, ensuring GMP-compliant execution and robust process performance.

You bring deep hands-on experience in fermentation-based processes, with proven ability to translate lab protocols into scalable manufacturing, while collaborating with production, QA and

Qualifications

• Bachelor’s or Master’s degree in Chemical Engineering, Biochemical Engineering, Biotechnology, Bioprocess Engineering, Pharmaceutical Engineering or a related discipline.
• Typically 10-20 years of relevant industrial experience in downstream process development, MSAT, process engineering, technology transfer or biomanufacturing.
• Substantial experience within the pharmaceutical, enzyme, industrial fermentation, biopharmaceutical or related biotechnology industries.
• Strong hands-on knowledge of fermentation-derived product recovery and purification.
• Experience scaling downstream processes from laboratory or pilot scale into commercial manufacturing.
• Strong understanding of GMP environments, sterile handling, contamination control, cleaning and controlled manufacturing practices.

Responsibilities

• Lead the technical transfer of customer downstream processes into ScaleUp Bio’s pilot and commercial manufacturing facilities.
• Assess customer process packages, identify technical gaps and translate laboratory-scale protocols into executable manufacturing processes.
• Develop and refine process flow diagrams, mass balances, operating parameters, equipment requirements and scale-up strategies.
• Evaluate process scalability, facility fit, equipment capability and operational risks before manufacturing.
• Design and execute engineering, verification, demonstration and manufacturing runs.
• Support downstream process scale-up across pilot and industrial production volumes.

Skills

Downstream processing

Process transfer

Scale-up expertise

GMP experience

Cross-functional leadership

Troubleshooting

Education

Bachelor’s or Master’s degree in Chemical Engineering, Biochemical Engineering, Biotechnology, Bioprocess Engineering, Pharmaceutical Engineering or a related discipline

Tools

Centrifugation

Microfiltration

Ultrafiltration

Depth filtration

Hydrophobic interaction chromatography

Ion-exchange chromatography

Affinity chromatography

Spray drying

Freeze drying

Job description

ScaleUp Bio, a Singapore-based fermentation CDMO, seeks a Senior MSAT Downstream Process Engineer to lead transfer, scale-up and optimisation of downstream operations. You will supervise centrifugation, filtration and chromatography steps, ensuring GMP-compliant execution and robust process performance.

You bring deep hands-on experience in fermentation-based processes, with proven ability to translate lab protocols into scalable manufacturing, while collaborating with production, QA and