Senior MSAT Downstream Process Engineer — Scale-Up Lead

Scaleup Bio; Singapore; On-site; SGD 180,000 - 280,000; Full time

Job summary

ScaleUp Bio is seeking a Senior MSAT Downstream Process Engineer in Singapore. You will lead the transfer, scale-up, optimisation and execution of downstream processing operations, with hands-on work across centrifugation, filtration and chromatography.

You will partner with Process Engineering, Production, Quality and Customer teams to ensure robust, compliant manufacturing results. The role requires deep biotechnology experience on fermentation-derived product recovery, process validation, and

Qualifications

• Bachelor’s or Master’s degree in Chemical Engineering, Biochemical Engineering, Biotechnology, Bioprocess Engineering or related discipline.
• Typically 10–20 years of relevant industrial experience in downstream process development, MSAT, process engineering, technology transfer or biomanufacturing.
• Substantial experience in pharmaceutical/enzymatic/biotech industries.
• Strong hands-on knowledge of downstream product recovery and purification.
• Experience scaling downstream processes from lab/pilot to commercial manufacturing.

Responsibilities

• Lead technical transfer of customer downstream processes into ScaleUp Bio’s pilot and commercial facilities.
• Translate laboratory-scale protocols into executable manufacturing processes with scale-up strategies.
• Develop mass balances, operating parameters, equipment needs and scale-up plans.
• Provide technical leadership for downstream unit operations and troubleshooting.
• Collaborate with cross-functional teams to ensure project deliverables meet GMP and quality requirements.

Skills

Project leadership

Process engineering

GMP experience

Data analysis

Troubleshooting

Communication skills

Education

Bachelor’s or Master’s degree in Chemical Engineering/bioprocess related

Tools

Centrifugation

Microfiltration

Ultrafiltration

Chromatography

Spray drying/Freeze drying

Job description

ScaleUp Bio is seeking a Senior MSAT Downstream Process Engineer in Singapore. You will lead the transfer, scale-up, optimisation and execution of downstream processing operations, with hands-on work across centrifugation, filtration and chromatography.

You will partner with Process Engineering, Production, Quality and Customer teams to ensure robust, compliant manufacturing results. The role requires deep biotechnology experience on fermentation-derived product recovery, process validation, and