Retinal Gene Therapy Scientist: CRISPR & Vector Design

A*STAR - Agency for Science, Technology and Research

Singapore

On-site

SGD 75,000 - 110,000

Full time

13 days ago

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Job summary

A*STAR – Agency for Science, Technology and Research invites a PhD scientist to join our laboratory as a Scientist. You will develop gene-editing and gene-therapy approaches for inherited retinal diseases and translate findings into preclinical proof-of-concept studies using rodent models.

The role involves CRISPR-based editing, AAV vector design, in-vitro and in-vivo assays, and collaboration within a translational team to advance retinal therapies.

Qualifications

PhD in molecular biology, cell biology, genetics, biomedical sciences, bioengineering, ophthalmology or related field.

Responsibilities

Design and optimize CRISPR-based gene-editing and vector strategies.
Construct and validate plasmids and AAV-based expression/editing systems.
Develop PCR, RT-qPCR, ddPCR and sequencing-based assays to assess editing and expression.
Perform rodent in-vivo studies for ocular delivery and therapeutic evaluation.
Lead data integration from molecular, cellular and in-vivo studies and present findings.
Contribute to publications, reports and grant applications; ensure biosafety compliance.

Skills

CRISPR gene editing

Molecular cloning

DNA assembly

AAV vectors

iPSCs

Mouse handling

Ocular imaging

Translational research

Data analysis

Team collaboration

Education

PhD in molecular biology/related field

Tools

PCR

RT-qPCR

ddPCR

NGS

Cell culture

Histology

Immunofluorescence

Job description

The role involves CRISPR-based editing, AAV vector design, in-vitro and in-vivo assays, and collaboration within a translational team to advance retinal therapies.

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