Scientist, Synthetic Biology & Gene Editing Therapeutics (GIS)

A*STAR RESEARCH ENTITIES; Singapore; On-site; SGD 67,000 - 100,000; Full time

Job summary

Genome Institute of Singapore, A*STAR invites applications for a Postdoctoral Scientist (PhD) to develop next-generation DNA and RNA editing technologies. You will join a team tackling CRISPR-Cas, insertion sequences, and polymerase engineering, exploring enzyme mining, protein engineering, functional genomics, and editor delivery in cells and animals.

Collaborating with clinicians, you will help build novel editors to correct disease mutations, aligning with GI Singapore’s research priorities

Qualifications

• Experience in molecular biology and gene editing.
• Experience with cell culture and high-throughput assays.
• Experience with Illumina and ONT sequencing preferred.
• Computational biology background preferred.

Responsibilities

• Develop DNA/RNA editing technologies within CRISPR-Cas and related areas.
• Engage in enzyme mining and design, protein and nucleic acid engineering.
• Contribute to functional genomics, editor delivery in cells and animals, and synthetic genomes.

Skills

Molecular biology

Enzyme engineering

Gene editing

Cell culture

High-throughput assays

Sequencing (Illumina/ONT)

Computational biology

Python/R

Job description

Build large DNA/RNA editors

We are recruiting a Postdoctoral Scientist (PhD) to develop the next generation of technologies for DNA and RNA editing.

You will be working with the team on some of the most interesting and hardest problems in CRISPR-Cas, Insertion Sequences (IS), and polymerase engineering. Depending on your research interests and expertise, this means enzyme mining & design, protein & nucleic acid engineering, functional genomics, editor delivery in cells and animals, and/or synthetic genomes. Novel technologies you develop will be used to correct disease mutations, through working with our team and clinician partners.

Job Requirements

Technical experience in molecular biology, enzyme:NA engineering, gene editing, cell culture, high-throughput assays, Illumina/ONT sequencing, computational biology, and/or Claude Code/R/python preferred. Strong desire to invent and explore scientific frontiers preferred.

More at: http://chewlab.github.io

Genome Institute of Singapore, A*STAR
The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.