Scientist, SXY Lab (IMCB) (2719)

A*STAR RESEARCH ENTITIES; Singapore; On-site; SGD 120,000 - 180,000; Full time

Job summary

Institute of Molecular and Cell Biology (IMCB) in Singapore seeks a Scientist for the Translational Retinal Research Laboratory. The role leads stem cell-derived retinal models, multi-omics analyses, and translational studies for AMD and other retinal diseases.

You will collaborate across disciplines to identify biomarkers, targets, and therapeutic strategies while mentoring junior researchers and contributing to publications and grants.

Qualifications

• PhD in a relevant biomedical field with a strong publication record.
• Independent, creative researcher able to design and troubleshoot experiments.
• Experience with retinal biology, stem cell biology or regenerative medicine is essential.
• Experience with omics approaches and data analysis is highly desirable.

Responsibilities

• Design, execute, and optimize experiments with stem cell-derived retinal cells (RPE and related populations).
• Develop in-vitro retinal disease models to study mechanisms and therapies.
• Generate and interpret complex datasets to identify pathways and targets.
• Collaborate with bioinformaticians, clinicians, and multidisciplinary teams.
• Contribute to development and evaluation of novel biologic therapies for retinal diseases.
• Mentor junior staff and interns in experimental design and data analysis.
• Present findings at meetings and conferences; contribute to collaborations.
• Prepare manuscripts and assist in grant proposals and reports.
• Maintain accurate records and ensure biosafety/compliance.

Skills

Retinal biology

Stem cell biology

Regenerative medicine

Cell culture

Gene expression analysis

Imaging

Immunohistochemistry

Functional assays

Single-cell sequencing

Bioinformatics

R/Python

Education

PhD in Stem Cell Biology, Neuroscience, Ophthalmology, Cell Biology, Molecular Biology, Biomedical Sciences, Bioengineering, or related discipline

Job description

Job Description

We are seeking a highly motivated and talented Scientist to join our Translational Retinal Research Laboratory @ Institute of Molecular and Cell Biology (IMCB). The successful candidate will lead innovative research programmes focused on understanding retinal disease mechanisms and developing nextgeneration therapies for Age-related Macular Degeneration {AMD) and other retinal diseases.

The Scientist will integrate advanced stem cell biology, retinal disease modelling, and multi-omics approaches to identify disease mechanisms, therapeutic targets, and biomarkers that can accelerate translational development and clinical impact.

Responsibilities

• Design, execute, and optimize experiments involving stem cell-derived retinal cell types, including retinal pigment epithelium (RPE) and related ocular cell populations.
• Develop and apply advanced in-vitro retinal disease models to investigate disease mechanisms and therapeutic interventions.
• Generate, analyse, and interpret complex biological datasets to identify disease-associated pathways, biomarkers, and therapeutic targets.
• Collaborate closely with bioinformaticians, clinicians, and multidisciplinary research teams to integrate molecular, cellular, imaging, and functional datasets.
• Contribute to the development and evaluation of novel biologic therapies for retinal diseases.
• Mentor Research Officers and interns in experimental design, laboratory techniques, and data analysis.
• Present research findings at internal meetings, scientific conferences, and external collaborations.
• Prepare manuscripts for publication in peer-reviewed journals and contribute to grant applications, progress reports, and intellectual property disclosures.
• Maintain accurate scientific records and ensure compliance with institutional, biosafety, and regulatory requirements.

Job Requirements

• PhD in Stem Cell Biology, Neuroscience, Ophthalmology, Cell Biology, Molecular Biology, Biomedical Sciences, Bioengineering, or a related discipline.
• Strong publication record demonstrating independent scientific contributions.
• Experience in one or more of the following areas:
• Retinal biology
• Stem cell biology
• Regenerative medicine
• Hands‑on experience with advanced molecular and cellular techniques including cell culture, gene expression analysis, imaging, immunohistochemistry, and functional assays.
• Experience with single‑cell sequencing, bioinformatics, or other omics-based technologies is highly desirable but not necessary.
• Familiarity with data analysis using R, Python, or related computational tools is advantageous.
• Demonstrated ability to independently design experiments, troubleshoot technical challenges, and drive projects forward.
• Excellent scientific writing, presentation, and communication skills.
• Strong collaborative mindset with the ability to work effectively in multidisciplinary teams.