Senior Scientist I, SXY Lab (IMCB)

A*STAR - Agency for Science, Technology and Research; Singapore; On-site; SGD 65,000 - 85,000; Full time

Job summary

A*STAR - Agency for Science, Technology and Research in Singapore is looking for a motivated Scientist to join the Translational Retinal Research Laboratory. The position focuses on developing innovative therapies for retinal diseases and offers opportunities in disease modelling and preclinical evaluation.

The ideal candidate should hold a PhD and possess strong experimental skills, with responsibilities including in-vitro disease models and therapeutic evaluation in rodent studies. Collaborative work and scientific communication are key components of this role.

Qualifications

• PhD in a relevant field with strong hands-on experience in cell culture.
• Demonstrated experience in rodent studies including injections and dissections.
• Ability to design, execute, and troubleshoot experiments independently.

Responsibilities

• Develop and perform in-vitro retinal disease models using stem cells.
• Conduct therapeutic evaluations and transplant studies in rodents.
• Perform in-vivo procedures including ocular injections and retinal imaging.

Skills

Experimental skills

Scientific communication

Teamwork

Project management

Education

PhD in Cell Biology, Molecular Biology, Neuroscience, Ophthalmology, Biomedical Sciences, or a related discipline

Tools

Cell culture and disease modelling techniques

Histology and immunofluorescence

Microscopy

Job description

Job Description

We are seeking a motivated Scientist to join our Translational Retinal Research Laboratory focused on developing innovative therapies for retinal diseases. The successful candidate will contribute to a combination of in‑vitro and in‑vivo studies, supporting therapeutic discovery, validation, and mechanistic investigations. The role offers opportunities to work across disease modelling, preclinical evaluation, and translational research within a multidisciplinary environment. Candidates with strong experimental skills, scientific curiosity, and a collaborative mindset are encouraged to apply.

Responsibilities

• Develop and perform in‑vitro retinal disease models using stem cell‑derived ocular cells.
• Conduct therapeutic evaluation and transplantation studies in rodent models of retinal disease.
• Perform in‑vivo procedures, including ocular injections, retinal imaging, tissue collection, and histological analyses.
• Assess therapeutic efficacy using molecular, cellular, imaging, and functional endpoints.
• Apply cell biology, molecular biology, and immunological techniques to investigate disease mechanisms and treatment outcomes.
• Analyse and present experimental data, and contribute to scientific publications, grant applications, and project reports.
• Collaborate with multidisciplinary teams and maintain compliance with laboratory, biosafety, and animal ethics standards.

Qualifications

Essential Qualifications

• PhD in Cell Biology, Molecular Biology, Neuroscience, Ophthalmology, Biomedical Sciences, or a related discipline.
• Strong hands‑on experience in cell culture and disease modelling.
• Demonstrated experience in rodent studies, including animal handling, injections, dissections, tissue collection, and experimental design.
• Experience with histology, immunofluorescence, microscopy, and molecular biology techniques.
• Ability to independently design, execute, and troubleshoot experiments.
• Strong data interpretation and scientific communication skills.
• Excellent teamwork and project management abilities.

Preferred Qualifications

• Experience in retinal biology, retinal degeneration, AMD, inherited retinal diseases, or ocular therapeutics.
• Experience with cell transplantation, regenerative medicine, stem cell‑derived products, or cell therapy development.
• Familiarity with retinal imaging modalities such as OCT, fundus photography, and fluorescein angiography.
• Experience evaluating therapeutic efficacy in preclinical disease models.
• Publication record demonstrating independent scientific contribution.