MES Engineer – After-Hours GMP Operations Expert

Sanofi Aventis Singapore Pte. Ltd; Singapore; On-site; SGD 120,000 - 150,000; Full time

Job summary

Sanofi Manufacturing & Supply in Tuas South, Singapore, is seeking an MES Specialist / MES Engineer to support operation, monitoring, and maintenance of the OpCenter Pharma MES within the Modulus project.

You will ensure GMP compliance, data integrity, and validation, handle incident management, PI modeling, master data, and collaborate across Manufacturing, QA, and Digital teams to enable uninterrupted production.

Qualifications

• Bachelor's degree in Engineering, Pharmaceutical, Life Sciences, or related field (or equivalent experience).
• 1–10 years of experience supporting or administering an MES in a GMP-regulated pharmaceutical, biotech, or similar manufacturing environment.
• Hands-on OpCenter Pharma experience.
• Experience with master data and PI/process definitions within an MES or similar manufacturing IT system.
• Experience in on-call / after-hours production support is a plus.

Responsibilities

• Support the day-to-day operation, monitoring, and maintenance of the OpCenter Pharma MES to ensure system availability, reliability, and performance.
• Ensure the MES functions correctly for production execution and EBR workflows.
• Participate in night call / after-hours support rotations, performing first-level troubleshooting and escalating complex issues as needed.
• Own the MES platform end-to-end, including operations, administration, and configuration, with minimal supervision.
• Prioritize MES incidents and keep the MES Manager and stakeholders informed of downtime and major incidents.
• Execute PI changes and master data updates in OpCenter Pharma, following established standards and change control procedures.
• Maintain a well-structured master data environment by applying and enforcing naming conventions, hierarchies, and data governance rules.
• Apply good PI modeling practices (modular, reusable, scalable), flagging and remediating suboptimal or legacy designs.
• Support investigations into MES incidents and deviations, including data gathering, documentation, and root cause analysis.
• Lead MES investigations where required, defining and implementing CAPA in line with GMP requirements.
• Ensure compliance with GxP, data integrity, and validation requirements in all MES configuration and change activities.
• Collaborate with Manufacturing (MFG), Quality Assurance (QA), Smart Factory, and Digital teams to translate business requirements into robust MES solutions.
• Advise MFG and QA on MES data, design, and system usage.
• Contribute to and maintain technical documentation, including SOPs, work instructions, and design specifications, to support audit readiness.

Skills

Analytical skills

Troubleshooting

Communication

Teamwork

Escalation judgment

Problem solving

Education

Bachelor's degree in Engineering, Pharmaceutical, Life Sciences, or related field

Tools

OpCenter Pharma

SQL

Scripting

MES integration with SCADA/ERP/PLC

CSV/CSA data integrity

Job description

Sanofi Manufacturing & Supply in Tuas South, Singapore, is seeking an MES Specialist / MES Engineer to support operation, monitoring, and maintenance of the OpCenter Pharma MES within the Modulus project.

You will ensure GMP compliance, data integrity, and validation, handle incident management, PI modeling, master data, and collaborate across Manufacturing, QA, and Digital teams to enable uninterrupted production.