MES Engineer/Specialist

Sanofi Aventis Singapore Pte. Ltd; Singapore; On-site; SGD 120,000 - 150,000; Full time

Job summary

Sanofi Manufacturing & Supply in Tuas South, Singapore, is seeking an MES Specialist / MES Engineer to support operation, monitoring, and maintenance of the OpCenter Pharma MES within the Modulus project.

You will ensure GMP compliance, data integrity, and validation, handle incident management, PI modeling, master data, and collaborate across Manufacturing, QA, and Digital teams to enable uninterrupted production.

Qualifications

• Bachelor's degree in Engineering, Pharmaceutical, Life Sciences, or related field (or equivalent experience).
• 1–10 years of experience supporting or administering an MES in a GMP-regulated pharmaceutical, biotech, or similar manufacturing environment.
• Hands-on OpCenter Pharma experience.
• Experience with master data and PI/process definitions within an MES or similar manufacturing IT system.
• Experience in on-call / after-hours production support is a plus.

Responsibilities

• Support the day-to-day operation, monitoring, and maintenance of the OpCenter Pharma MES to ensure system availability, reliability, and performance.
• Ensure the MES functions correctly for production execution and EBR workflows.
• Participate in night call / after-hours support rotations, performing first-level troubleshooting and escalating complex issues as needed.
• Own the MES platform end-to-end, including operations, administration, and configuration, with minimal supervision.
• Prioritize MES incidents and keep the MES Manager and stakeholders informed of downtime and major incidents.
• Execute PI changes and master data updates in OpCenter Pharma, following established standards and change control procedures.
• Maintain a well-structured master data environment by applying and enforcing naming conventions, hierarchies, and data governance rules.
• Apply good PI modeling practices (modular, reusable, scalable), flagging and remediating suboptimal or legacy designs.
• Support investigations into MES incidents and deviations, including data gathering, documentation, and root cause analysis.
• Lead MES investigations where required, defining and implementing CAPA in line with GMP requirements.
• Ensure compliance with GxP, data integrity, and validation requirements in all MES configuration and change activities.
• Collaborate with Manufacturing (MFG), Quality Assurance (QA), Smart Factory, and Digital teams to translate business requirements into robust MES solutions.
• Advise MFG and QA on MES data, design, and system usage.
• Contribute to and maintain technical documentation, including SOPs, work instructions, and design specifications, to support audit readiness.

Skills

Analytical skills

Troubleshooting

Communication

Teamwork

Escalation judgment

Problem solving

Education

Bachelor's degree in Engineering, Pharmaceutical, Life Sciences, or related field

Tools

OpCenter Pharma

SQL

Scripting

MES integration with SCADA/ERP/PLC

CSV/CSA data integrity

Job description

Overview

Sanofi Manufacturing & Supply is preparing its future through an ambitious program named Modulus. The Modulus Project is at the cornerstone of Sanofi's strategy, aiming to create a new generation of evolutive multi-product facilities that are modular, adaptable, and agile, while leveraging disruptive technologies to better address vaccine and biologics manufacturing challenges.

The MES Specialist / MES Engineer is responsible for supporting the operation, monitoring, maintenance, and continuous improvement of the OpCenter Pharma Manufacturing Execution System (MES) within the Modulus Singapore facility. The role ensures the MES operates reliably and in compliance with GxP, data integrity, and validation requirements, supporting uninterrupted production execution and electronic batch record (EBR) workflows.

Key Responsibilities

MES Operations & Support

• Support the day-to-day operation, monitoring, and maintenance of the OpCenter Pharma MES to ensure system availability, reliability, and performance.


• Ensure the MES functions correctly for production execution and EBR workflows.


• Participate in night call / after-hours support rotations, performing first-level troubleshooting and escalating complex issues as needed.


• Own the MES platform end-to-end, including operations, administration, and configuration, with minimal supervision.


• Prioritize MES incidents and keep the MES Manager and stakeholders informed of downtime and major incidents.

PI Modeling & Master Data Management

• Execute PI changes and master data updates in OpCenter Pharma, following established standards and change control procedures.


• Maintain a well-structured master data environment by applying and enforcing naming conventions, hierarchies, and data governance rules.


• Apply good PI modeling practices (modular, reusable, scalable), flagging and remediating suboptimal or legacy designs.

Investigations, Deviations & Compliance

• Support investigations into MES incidents and deviations, including data gathering, documentation, and root cause analysis.


• Lead MES investigations where required, defining and implementing CAPA in line with GMP requirements.


• Ensure compliance with GxP, data integrity, and validation requirements in all MES configuration and change activities.

Cross-Functional Collaboration & Documentation

• Collaborate with Manufacturing (MFG), Quality Assurance (QA), Smart Factory, and Digital teams to translate business requirements into robust MES solutions.


• Advise MFG and QA on MES data, design, and system usage.


• Contribute to and maintain technical documentation, including SOPs, work instructions, and design specifications, to support audit readiness.

Core Competencies

• Working knowledge of OpCenter Pharma or similar MES platforms, including configuration and administration.


• Understanding of PI modeling concepts and manufacturing execution in a pharmaceutical setting.


• Familiarity with GxP, data integrity, CSV/CSA, and change control principles.


• Strong analytical and troubleshooting skills with a structured problem-solving approach.


• Effective communication, teamwork, and sound escalation judgment.


• SQL or scripting skills are a plus; knowledge of MES integration with SCADA, ERP, PLCs, or Smart Factory/IIoT platforms is an advantage.

Technical & Educational Background

• Bachelor's degree in Engineering, Pharmaceutical, Life Sciences, or a related field (or equivalent experience).


• 1–10 years of experience supporting or administering an MES in a GMP-regulated pharmaceutical, biotech, or similar manufacturing environment.


• Hands-on OpCenter Pharma experience.


• Experience with master data and PI/process definitions within an MES or similar manufacturing IT system.


• Experience in on-call / after-hours production support is a plus.

Job Expectations

• Based in Tuas South, Singapore.


• Participation in night call / after-hours support rotations for MES issues.


• May require operational standby support for critical system breakdowns.

Pursue progress, discover extraordinary

Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.

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