Research Fellowship (MSc) – Translational Immunology

iBET; Oeiras; Vor Ort; EUR 13.000 - 20.000; Vollzeit

Zusammenfassung

iBET is offering a Research Fellowship (MSc) in Translational Immunology within the AdCAM project. The role focuses on hiPSC-derived macrophages, enabling scalable bioprocessing and CAR constructs. Strong emphasis on teamwork, independent work, and clear scientific communication.

The candidate should hold a Master’s in a related field, have experience with hPSC and genetic engineering, and demonstrate proficiency in English. The fellowship lasts 12 months with a March 1, 2026 start date.

Qualifikationen

• Master’s degree with average grade of at least 18.
• Experience working with human pluripotent stem cells (hPSC) and genetic engineering.
• Good command of English, spoken and written.

Aufgaben

• Culture and differentiate hiPSC into macrophages.
• Genomic engineering using CRISPR and cassette exchange.
• Culture in bioreactors and scale-up production.
• Functionally characterize cells by qPCR, flow cytometry and microscopy.

Kenntnisse

Molecular biology

Stem cell culture

Analytical methods

Data analysis software

Scientific communication

Ausbildung

Master’s degree in Biological, Chemical or Biomedical Engineering, Biotechnology, Biology, Biochemistry, Immunology, or related areas

Tools

GraphPad Prism

ImageJ

FlowJo

R

Jobbeschreibung

Research Fellowship (MSc) – Translational Immunology

iBET,has an open position for a research fellowship in the field of Translational Immunology available within the project “AdCAM – Scalable bioprocessing of engineered hiPSC-derived macrophages with an adaptable CAR“, financed by iBETXplore.

Master’s degree in Biological, Chemical or Biomedical Engineering, Biotechnology, Biology, Biochemistry, Immunology, or related areas, with an average classification of at least 18.

The candidate should have experience in working with human pluripotent stem cells (hPSC) and hPSC genetic engineering.

We value knowledge and experience in the following topics:

• Molecular biology methods (including PCR, qRT-PCR, vector cloning, cell transfection and transduction of lentivirus).
• Human pluripotent stem cell culture.
• Analytical methods (fluorescence microscopy, flow cytometry, functional assays).
• Relevant software for data analysis and visualization (e.g. GraphPad Prism, ImageJ, FlowJo, R)
• Analysis, discussion, and presentation of scientific data (e.g. conferences talk, posters and peer-reviewed publications).

The candidate is expected to be motivated, self-driven, and able to work in a team, but also independently.

Good command of the English language, both spoken and written, is required (candidates with internships and/or periods abroad will be valued).

Engineering human induced pluripotent stem cells (hiPSC) to generate a hiPSC-derived macrophage cell line that expresses a CAR construct and establishing the scale‑up production in bioreactors. Main tasks include:

• Culture and cell differentiation of hiPSC into macrophages.
• Genomic engineering of cells using CRISPR and recombinant mediated cassette exchange.
• Culture cells and differentiation in bioreactors.
• Functional characterization of cells by qPCR, Flow Cytometry and microscopy.

The fellowship will have a duration of 12months, eventually renewed until the end of project, without prejudice of the maximum limits foreseen by law. The expected starting date is 1 of March of 2026.