PhD: Oligodendrocyte-Targeted Gene Therapy for PMLD1

SIGRA; Amsterdam; On-site; EUR 20,000 - 27,000; Full time

Job summary

Cyprus Institute of Neurology & Genetics (CING) in Nicosia, Cyprus, offers a PhD position within the POLARIS doctoral network focused on leukodystrophies. You will work on isogenic iPSC-derived myelinating organoids and test AAV variants in collaboration with the POLARIS consortium.

The role combines in vitro disease modelling with in vivo validation using mouse models, including behavioural phenotyping and ethical compliance, under expert supervision.

Qualifications

• Master's degree in Life Sciences, preferably in Neuroscience.
• Strong interest in translational neuroscience and rare disease research.
• Hands-on experience with in vivo mouse research is desired.

Responsibilities

• Establish isogenic iPSC-derived myelinating organoids as a disease model.
• Test AAV variants and assess effects on myelination and oligodendrocyte survival.
• Use mouse models to evaluate therapeutic potential in vivo.
• Apply behavioural and neurological phenotyping to assess mechanisms and treatment responses.
• Collaborate with researchers at CING and POLARIS consortium.

Skills

In vivo mouse work

Behavioral phenotyping

Neurobiology knowledge

Analytical thinking

Communication skills

Education

Master's degree in Life Sciences

Tools

None

Job description

Cyprus Institute of Neurology & Genetics (CING) in Nicosia, Cyprus, offers a PhD position within the POLARIS doctoral network focused on leukodystrophies. You will work on isogenic iPSC-derived myelinating organoids and test AAV variants in collaboration with the POLARIS consortium.

The role combines in vitro disease modelling with in vivo validation using mouse models, including behavioural phenotyping and ethical compliance, under expert supervision.