PhD: Gene Therapy for Leukodystrophies (Preclinical)

Amsterdam UMC; Amsterdam; On-site; EUR 39,000 - 49,000; Full time

Benefits offered by this job

Living allowance

Mobility allowance

Family allowance

Pension ABP

Transport reimbursement

Bicycle scheme

GoodHabitz access

Staff association and events

Job summary

Amsterdam UMC, in an international, interdisciplinary setting, invites applications for a doctoral candidate to contribute to preclinical development of gene therapy for leukodystrophies. You will work on AAV efficacy in mouse models, apply genome-editing, and analyse results to align preclinical readouts with clinical outcomes.

You will collaborate across POLARIS partner organisations, benefit from doctoral training, and develop transferable skills within a vibrant research environment.

Qualifications

• Master’s degree in life sciences or related discipline.
• Fluency in English, written and spoken.
• Formal FELASA or equivalent animal-work qualification preferred.
• Interest in translational neuroscience and rare disease research.

Responsibilities

• Test efficacy and safety of AAV gene therapy in mouse models.
• Apply genome-editing approaches to assess therapeutic efficacy.
• Use molecular techniques and in vivo mouse models to study disease mechanisms.
• Analyze results and align preclinical readouts with clinical outcomes.
• Collaborate with Amsterdam UMC and POLARIS partners; participate in trainings.

Skills

Molecular techniques

Viral vectors

Data analysis

Communication

Team collaboration

Education

Master's degree

Life sciences

Molecular sciences

Tools

FELASA certification

Job description

Amsterdam UMC, in an international, interdisciplinary setting, invites applications for a doctoral candidate to contribute to preclinical development of gene therapy for leukodystrophies. You will work on AAV efficacy in mouse models, apply genome-editing, and analyse results to align preclinical readouts with clinical outcomes.

You will collaborate across POLARIS partner organisations, benefit from doctoral training, and develop transferable skills within a vibrant research environment.