PhD: Oligodendrocyte Gene Therapy for PMLD1

Amsterdam UMC; Netherlands; On-site; EUR 32,000 - 42,000; Full time

Job summary

Amsterdam UMC through the POLARIS doctoral network invites applications for a First Stage Researcher (R1) to pursue a PhD in Neuroscience focusing on isogenic iPSC-derived myelinating organoids and gene therapy approaches for Pelizaeus-Merzbacher-like disease type 1 (PMLD1). The position is based in Nicosia, Cyprus, with secondments and training across Europe.

Applicants should hold a Master’s degree in Life Sciences (preferably Neuroscience) and demonstrate fluency in English, robust

Qualifications

• Fluency in English (written and spoken) is essential.
• Strong analytical and problem-solving abilities are required.

Responsibilities

• Establish isogenic iPSC-derived myelinating organoids as a disease model.
• Test AAV variants for effects on myelination and oligodendrocyte survival.
• Use a mouse model to evaluate therapeutic potential in vivo.
• Engage in network-wide training and secondments within POLARIS consortium.

Skills

English fluency

Analytical & problem-solving

Education

Master's degree in Life Sciences (Neuroscience preferred)

Job description

Amsterdam UMC through the POLARIS doctoral network invites applications for a First Stage Researcher (R1) to pursue a PhD in Neuroscience focusing on isogenic iPSC-derived myelinating organoids and gene therapy approaches for Pelizaeus-Merzbacher-like disease type 1 (PMLD1). The position is based in Nicosia, Cyprus, with secondments and training across Europe.

Applicants should hold a Master’s degree in Life Sciences (preferably Neuroscience) and demonstrate fluency in English, robust